Perineuronal nets (PNNs) are extracellular matrix (ECM) chondroitin sulfate proteoglycan
(CSPG)-containing structures that surround the soma and dendrites of various mammalian …

Drug development is a lengthy and costly process that proceeds through several stages
from target identification to lead discovery and optimization, preclinical validation and …

Many processes in the human body—including brain function—are regulated over the 24-
hour cycle, and there are strong associations between disrupted circadian rhythms (for …

The biochemical and biophysical properties of the extracellular matrix (ECM) dictate tissue-
specific cell behaviour. The molecules that are associated with the ECM of each tissue …

Perineuronal nets (PNNs) are unique extracellular matrix structures that wrap around certain
neurons in the CNS during development and control plasticity in the adult CNS. They appear …

Memory, defined as the storage and use of learned information in the brain, is necessary to
modulate behavior and critical for animals to adapt to their environments and survive …

Background Perineuronal nets (PNNs) are extracellular matrix structures that enwrap many
neurons in the brain. They regulate the postnatal experience-dependent maturation of brain …

The diverse functions of glial cells prompt the question to which extent specific subtypes may
be devoted to a specific function. We discuss this by reviewing one of the most recently …

There are currently more than 600 diseases characterized as affecting the central nervous
system (CNS) which inflict neural damage. Unfortunately, few of these conditions have …

There is increasing interest in defining the location, content, and role of extracellular matrix
(ECM) components in brain structure and function during development, aging, injury, and …