The mechanism of genome replication and transcription in bunyaviruses

H Malet, HM Williams, S Cusack, M Rosenthal - PLoS pathogens, 2023 - journals.plos.org
Bunyaviruses are negative sense, single-strand RNA viruses that infect a wide range of
vertebrate, invertebrate and plant hosts. WHO lists three bunyavirus diseases as priority …

Peroxiredoxins—the underrated actors during virus-induced oxidative stress

IL Karpenko, VT Valuev-Elliston, ON Ivanova… - Antioxidants, 2021 - mdpi.com
Enhanced production of reactive oxygen species (ROS) triggered by various stimuli,
including viral infections, has attributed much attention in the past years. It has been shown …

Structural basis for recognition and regulation of arenavirus polymerase L by Z protein

H Kang, J Cong, C Wang, W Ji, Y Xin, Y Qian… - Nature …, 2021 - nature.com
Junin virus (JUNV) causes Argentine hemorrhagic fever, a debilitating human disease of
high mortality rates and a great risk to public health worldwide. Studying the L protein that …

Orchestration of protein acetylation as a toggle for cellular defense and virus replication

LA Murray, X Sheng, IM Cristea - Nature communications, 2018 - nature.com
Emerging evidence highlights protein acetylation, a prevalent lysine posttranslational
modification, as a regulatory mechanism and promising therapeutic target in human viral …

[HTML][HTML] SARS-CoV-2 Nsp14 activates NF-κB signaling and induces IL-8 upregulation

T Li, AD Kenney, H Liu, GN Fiches, D Zhou, A Biswas… - BioRxiv, 2021 - ncbi.nlm.nih.gov
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leads to NF-κB
activation and induction of pro-inflammatory cytokines, though the underlying mechanism for …

SARS-CoV-2 Nsp14 protein associates with IMPDH2 and activates NF-κB signaling

TW Li, AD Kenney, JG Park, GN Fiches, H Liu… - Frontiers in …, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leads to NF-κB
activation and induction of pro-inflammatory cytokines, though the underlying mechanism for …

Characterization of bi-segmented and tri-segmented recombinant Pichinde virus particles

H Murphy, Q Huang, J Jensen, N Weber… - Journal of …, 2024 - journals.asm.org
Mammarenaviruses include several highly virulent pathogens (eg, Lassa virus) capable of
causing severe hemorrhagic fever diseases for which there are no approved vaccines and …

The virus–host interplay in Junín mammarenavirus infection

GL Gallo, N López, ME Loureiro - Viruses, 2022 - mdpi.com
Junín virus (JUNV) belongs to the Arenaviridae family and is the causative agent of
Argentine hemorrhagic fever (AHF), a severe human disease endemic to agricultural areas …

Targeting n-myristoyltransferases promotes a pan-Mammarenavirus inhibition through the degradation of the Z matrix protein

X Carnec, V Borges-Cardoso, S Reynard… - PLoS …, 2024 - journals.plos.org
Several Old World and New World Mammarenavirus are responsible for hemorrhagic fever
in humans. These enveloped viruses have a bi-segmented ambisense RNA genome that …

Lifecycle modelling systems support inosine monophosphate dehydrogenase (IMPDH) as a pro-viral factor and antiviral target for New World arenaviruses

EC Dunham, A Leske, K Shifflett, A Watt, H Feldmann… - Antiviral research, 2018 - Elsevier
Infection with Junín virus (JUNV) is currently being effectively managed in the endemic
region using a combination of targeted vaccination and plasma therapy. However, the long …