Immune determinants of chronic sequelae after respiratory viral infection
The acute effects of various respiratory viral infections have been well studied, with
extensive characterization of the clinical presentation as well as viral pathogenesis and host …
extensive characterization of the clinical presentation as well as viral pathogenesis and host …
Spike and nsp6 are key determinants of SARS-CoV-2 Omicron BA. 1 attenuation
Abstract The SARS-CoV-2 Omicron variant is more immune evasive and less virulent than
other major viral variants that have so far been recognized,,,,,,,,,,–. The Omicron spike (S) …
other major viral variants that have so far been recognized,,,,,,,,,,–. The Omicron spike (S) …
SARS-CoV-2 immunity in animal models
Z Chen, Y Yuan, Q Hu, A Zhu, F Chen, S Li… - Cellular & molecular …, 2024 - nature.com
The COVID-19 pandemic, which was caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has become a worldwide health crisis due to its …
coronavirus 2 (SARS-CoV-2), has become a worldwide health crisis due to its …
Neuroinvasion and neurotropism by SARS-CoV-2 variants in the K18-hACE2 mouse
F Seehusen, JJ Clark, P Sharma, EG Bentley, A Kirby… - Viruses, 2022 - mdpi.com
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) not only affects the
respiratory tract but also causes neurological symptoms such as loss of smell and taste …
respiratory tract but also causes neurological symptoms such as loss of smell and taste …
The stereotypic response of the pulmonary vasculature to respiratory viral infections: Findings in mouse models of SARS-CoV-2, influenza A and gammaherpesvirus …
S De Neck, R Penrice-Randal, JJ Clark, P Sharma… - Viruses, 2023 - mdpi.com
The respiratory system is the main target of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), the cause of coronavirus disease 19 (COVID-19) where acute respiratory …
(SARS-CoV-2), the cause of coronavirus disease 19 (COVID-19) where acute respiratory …
Evolution of ACE2-independent SARS-CoV-2 infection and mouse adaption after passage in cells expressing human and mouse ACE2
Human ACE2 Human angiotensin converting enzyme 2 (hACE2) is the key cell attachment
and entry receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with …
and entry receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with …
[HTML][HTML] Warmer ambient air temperatures reduce nasal turbinate and brain infection, but increase lung inflammation in the K18-hACE2 mouse model of COVID-19
Warmer climatic conditions have been associated with fewer COVID-19 cases. Herein we
infected K18-hACE2 mice housed at the standard animal house temperature of∼ 22° C, or …
infected K18-hACE2 mice housed at the standard animal house temperature of∼ 22° C, or …
Emerging role of kinin B1 receptor in persistent neuroinflammation and neuropsychiatric symptoms in mice following recovery from SARS-CoV-2 infection
S Sriramula, D Theobald, RU Parekh, SM Akula… - Cells, 2023 - mdpi.com
Evidence suggests that patients with long COVID can experience neuropsychiatric,
neurologic, and cognitive symptoms. However, these clinical data are mostly associational …
neurologic, and cognitive symptoms. However, these clinical data are mostly associational …
SARS-CoV-2 omicron BA. 5 and XBB variants have increased neurotropic potential over BA. 1 in K18-hACE2 mice and human brain organoids
The reduced pathogenicity of the omicron BA. 1 sub-lineage compared to earlier variants is
well described, although whether such attenuation is retained for later variants like BA. 5 …
well described, although whether such attenuation is retained for later variants like BA. 5 …
Mouse-Adapted SARS-CoV-2 MA10 Strain Displays Differential Pulmonary Tropism and Accelerated Viral Replication, Neurodissemination, and Pulmonary Host …
CJ Thieulent, W Dittmar, UBR Balasuriya… - Msphere, 2023 - Am Soc Microbiol
Several models were developed to study the pathogenicity of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) as well as the in vivo efficacy of vaccines and …
syndrome coronavirus 2 (SARS-CoV-2) as well as the in vivo efficacy of vaccines and …