Immune determinants of chronic sequelae after respiratory viral infection

H Narasimhan, Y Wu, NP Goplen, J Sun - Science Immunology, 2022 - science.org
The acute effects of various respiratory viral infections have been well studied, with
extensive characterization of the clinical presentation as well as viral pathogenesis and host …

Spike and nsp6 are key determinants of SARS-CoV-2 Omicron BA. 1 attenuation

DY Chen, CV Chin, D Kenney, AH Tavares, N Khan… - Nature, 2023 - nature.com
Abstract The SARS-CoV-2 Omicron variant is more immune evasive and less virulent than
other major viral variants that have so far been recognized,,,,,,,,,,–. The Omicron spike (S) …

SARS-CoV-2 immunity in animal models

Z Chen, Y Yuan, Q Hu, A Zhu, F Chen, S Li… - Cellular & molecular …, 2024 - nature.com
The COVID-19 pandemic, which was caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has become a worldwide health crisis due to its …

Neuroinvasion and neurotropism by SARS-CoV-2 variants in the K18-hACE2 mouse

F Seehusen, JJ Clark, P Sharma, EG Bentley, A Kirby… - Viruses, 2022 - mdpi.com
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) not only affects the
respiratory tract but also causes neurological symptoms such as loss of smell and taste …

The stereotypic response of the pulmonary vasculature to respiratory viral infections: Findings in mouse models of SARS-CoV-2, influenza A and gammaherpesvirus …

S De Neck, R Penrice-Randal, JJ Clark, P Sharma… - Viruses, 2023 - mdpi.com
The respiratory system is the main target of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), the cause of coronavirus disease 19 (COVID-19) where acute respiratory …

Evolution of ACE2-independent SARS-CoV-2 infection and mouse adaption after passage in cells expressing human and mouse ACE2

K Yan, T Dumenil, B Tang, TT Le, CR Bishop… - Virus …, 2022 - academic.oup.com
Human ACE2 Human angiotensin converting enzyme 2 (hACE2) is the key cell attachment
and entry receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with …

[HTML][HTML] Warmer ambient air temperatures reduce nasal turbinate and brain infection, but increase lung inflammation in the K18-hACE2 mouse model of COVID-19

T Dumenil, TT Le, DJ Rawle, K Yan, B Tang… - Science of The Total …, 2023 - Elsevier
Warmer climatic conditions have been associated with fewer COVID-19 cases. Herein we
infected K18-hACE2 mice housed at the standard animal house temperature of∼ 22° C, or …

Emerging role of kinin B1 receptor in persistent neuroinflammation and neuropsychiatric symptoms in mice following recovery from SARS-CoV-2 infection

S Sriramula, D Theobald, RU Parekh, SM Akula… - Cells, 2023 - mdpi.com
Evidence suggests that patients with long COVID can experience neuropsychiatric,
neurologic, and cognitive symptoms. However, these clinical data are mostly associational …

SARS-CoV-2 omicron BA. 5 and XBB variants have increased neurotropic potential over BA. 1 in K18-hACE2 mice and human brain organoids

R Stewart, K Yan, SA Ellis, CR Bishop… - Frontiers in …, 2023 - frontiersin.org
The reduced pathogenicity of the omicron BA. 1 sub-lineage compared to earlier variants is
well described, although whether such attenuation is retained for later variants like BA. 5 …

Mouse-Adapted SARS-CoV-2 MA10 Strain Displays Differential Pulmonary Tropism and Accelerated Viral Replication, Neurodissemination, and Pulmonary Host …

CJ Thieulent, W Dittmar, UBR Balasuriya… - Msphere, 2023 - Am Soc Microbiol
Several models were developed to study the pathogenicity of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) as well as the in vivo efficacy of vaccines and …