Betulin, a pentacyclic triterpene and a plant pentacyclic triterpene metabolite, can be found
in large quantities in the outer bark of the birches (Betula, Betulaceae). Betulinic acid …

Saponins are widely distributed plant natural products with vast structural and functional
diversity. They are typically composed of a hydrophobic aglycone, which is extensively …

Numerous plant‐derived substances, and their derivatives, are effective antitumour and
chemopreventive agents. Yet, there are also a plethora of tumour types that do not respond …

Triterpenes are compounds of natural origin, which have numerously biological activities:
anti-cancer properties, anti-inflammatory, anti-oxidative, anti-viral, anti-bacterial and anti …

Betulin is a natural triterpene, usually from birch bark, known for its potential wound-healing
properties. Despite having a wide range of pharmacological targets, no studies have …

Introduction: Betulinic acid (BA) is a triterpenoid that can be obtained from renewable
resources. BA is cytotoxic to many human tumor cell lines mainly by apoptosis but cell death …

The haemolysis of red blood cells inducing toxicity in most animals including humans is a
major drawback for the clinical development of saponins as antitumour agents. In this study …

New therapies using novel mechanisms to induce tumor cell death are needed with plants
playing a crucial role as a source for potential anticancer compounds. One highly promising …

Saponins are bioactive compounds produced mainly by plants but also by some marine
organisms and insects. In the recent past, there has been unforeseen interest in the clinical …

The methodological developments in gold (I)-and gold (III)-catalyzed glycosylation reactions
are fully surveyed, which exploit the special alkynophilicity or the Lewis acidity of the gold …