During malignant progression cancer cells undergo a series of changes, which promote
their survival, invasiveness and metastatic process. One of them is a change in glucose …

The sustenance of human life activities depends on copper, which also serves as a crucial
factor for vital enzymes. Under typical circumstances, active homeostatic mechanisms keep …

Abstract N6-Methyladenosine (m6A) is the most prevalent RNA modification in various types
of RNA, including circular RNAs (circRNAs). Mounting evidence has shown that circRNAs …

Purpose: Cuproptosis, a form of copper-induced cell death, can be a promising therapeutic
target for refractory cancers. Hence, we conducted this research to explore the association …

Introduction Breast cancer (BC) has been ranking first in incidence and the leading cause of
death among female cancers worldwide based on the latest report. Regulated cell death …

Abstract Pyruvate dehydrogenase A1 (PDHA1) is a component of the pyruvate
dehydrogenase enzyme complex, which links glycolysis and the tricarboxylic acid cycle, and …

Ovarian cancer (OC) is a common reason for gynecologic cancer death. Standard
treatments of OC consist of surgery and chemotherapy. However, chemoresistance should …

Pyruvate dehydrogenase kinase 1 (PDK1) is overexpressed in ovarian cancer and thus is a
promising anticancer therapeutic target. Our previous work suggests that coumarin …

Based on TCGA, GTEx, and TIMER databases and various bioinformatics analysis methods,
the potential biological roles of cuprotosis‐related genes in pancreatic cancer were deeply …

Abstract Background and Objectives The metabolic network of cancer cells has been
reprogrammed–relying more on aerobic glycolysis to gain energy, which is an important …