The use of aerosolized bacteriophages as surrogates for hazardous viruses might simplify
and accelerate the discovery of links between viral components and their persistence in the …

During production of therapeutic monoclonal antibodies (mAbs) in mammalian cell culture, it
is important to ensure that viral impurities and potential viral contaminants will be removed …

Virus filtration and ultrafiltration are critical technologies that play unique roles in all antibody
purification processes. The need to remove both retroviral as well as potential adventitious …

Constant flux virus filtration experiments were conducted to evaluate minute virus of mice
retention behavior of four commercial virus filters for continuous bioprocessing applications …

We designed small‐scale virus filtration models to investigate the impact of the extended
process times and dynamic product streams present in continuous manufacturing. Our data …

Nanofiltration technology to remove possible pathogenic viruses during biopharmaceutical
manufacturing was introduced in the biopharmaceutical industry in 1989. The very first …

Although viral clearance experiments are designed to reproduce actual process conditions
at very small scale, in some cases the results of such studies are not always scalable from …

Recombinant adeno-associated viral vectors (rAAV) are being developed as gene therapy
delivery vehicles and as genetic vaccines, and some of the most scaleable manufacturing …

MATERIALS AND METHODS Optiscale-25 devices with Viresolve NFP membranes (3.5
cm2) were purchased from Millipore. Such filters are designed to be used in normal flow …

Virus removal filtration processes in biopharmaceutical manufacturing are developed,
optimized and validated for viral clearance using laboratory scale filters. Thus, the scalability …