Myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a recently
identified autoimmune disorder that presents in both adults and children as CNS …

Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) is the
most recently defined inflammatory demyelinating disease of the central nervous system …

In the past 15 years, B cells have been rediscovered to be not merely bystanders but rather
active participants in autoimmune aetiology. This has been fuelled in part by the clinical …

Oligodendrocytes generate multiple layers of myelin membrane around axons of the central
nervous system to enable fast and efficient nerve conduction. Until recently, saltatory nerve …

Anti-myelin oligodendrocyte glycoprotein (MOG) antibodies (MOG-Abs) were first detected
by immunoblot and enzyme-linked immunosorbent assay nearly 30 years ago, but their …

B cells are essential components of the adaptive immune system and have important roles
in the pathogenesis of several central nervous system (CNS) diseases. Besides producing …

There is growing recognition that B cell contributions to normal immune responses extend
well beyond their potential to become antibody-producing cells, including roles at the innate …

Conformation-sensitive antibodies against myelin oligodendrocyte glycoprotein (MOG) are
detectable in patients with optic neuritis, myelitis, opticomyelitis, acute or multiphasic …

Acute disseminated encephalomyelitis (ADEM) is an immune-mediated demyelinating CNS
disorder with predilection to early childhood. ADEM is generally considered a monophasic …

Importance Myelin oligodendrocyte glycoprotein antibodies (MOG-Abs) are consistently
identified in a range of demyelinating disorders in adults and children. Current therapeutic …