Astrocytes are no longer seen as a homogenous population of cells. In fact, recent studies
indicate that astrocytes are morphologically and functionally diverse and play critical roles in …

Oligodendrocytes and astrocytes are macroglial cells of the vertebrate central nervous
system. These cells have diverse roles in the maintenance of neurological function. In the …

The mechanistic basis of gliogenesis, which occurs late in human development, is poorly
understood. Here we identify nuclear factor IA (NFIA) as a molecular switch inducing human …

Transcriptional cascades that operate over the course of lineage development are
fundamental mechanisms that control cellular differentiation. In the developing central …

During development of the mammalian nervous system, neural stem cells generate neurons
first and glia second, thereby allowing the initial establishment of neural circuitry, and …

Astrocytes can be generated from various tissue sources including human pluripotent stem
cells (PSC). In this manuscript, we describe a chemically defined xeno-free medium culture …

The mechanisms controlling the transition from neurogenesis to gliogenesis in the
vertebrate CNS are incompletely understood. We identified a family of transcription factors …

Astrocytes play essential roles in brain function by supporting synaptic connectivity and
associated circuits. How these roles are regulated by transcription factors is unknown …

The N uclear F actor I (NFI) family of site-specific DNA-binding proteins (also known as CTF
or C AAT box t ranscription f actor) functions both in viral DNA replication and in the …

Sp1 belongs to the 26 member strong Sp/KLF family of transcription factors. It is a paradigm
for a ubiquitously expressed transcription factor and is involved in regulating the expression …