It has been one and a half centuries since Enrico Sertoli published the seminal discovery of
the testicular 'nurse cell', not only a key cell in the testis, but indeed one of the most amazing …

Male factor infertility is increasing in developed countries, and several factors linked to
lifestyle have been shown to negatively affect spermatogenesis. Sertoli cells are pivotal to …

The mammalian spermatozoa produced in the testis require functional maturation in the
epididymis for their full competence. Epididymal sperm maturation is regulated by lumicrine …

Androgens such as testosterone are steroid hormones essential for normal male
reproductive development and function. Mutations of androgen receptors (AR) are often …

Diabetes mellitus (DM) is one of the greatest public health threats in modern societies.
Although during a few years it was suggested that DM had no significant effect in male …

Testis size and sperm production are directly correlated to the total number of adult Sertoli
cells (SCs). Although the establishment of an adequate number of SCs is crucial for future …

Hormonal regulation is essential to spermatogenesis. Sertoli cells (SCs) have functions that
reach far beyond the physical support of germ cells, as they are responsible for creating the …

Rationale: Busulfan is currently an indispensable anti-cancer drug, particularly for children,
but the side effects on male reproduction are so serious that critical drug management is …

Low fertility of dairy cattle during the summer in tropical, subtropical and temperate regions
is a well-documented event. A less well-known fact is that during the autumn, although the …

Otto Warburg observed that cancerous cells prefer fermentative instead of oxidative
metabolism of glucose, although the former is in theory less efficient. Since Warburg's …