Crosslinking agents and methods of use

CP Pathak - US Patent 6,887,974, 2005 - Google Patents
Polymeric crosslinking agents are disclosed that have an inert water soluble polymeric
component, biodegradable components, functional components reactive with chemical …

Modified FGF-21 polypeptides and their uses

TP Cujec, R Mariani, AMAH PUTNAM… - US Patent …, 2011 - Google Patents
2008-08-19 Assigned to AMBRX, INC. reassignment AMBRX, INC. ASSIGNMENT OF
ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: KRAYNOV, VADIM …

Method for the preparation of 1-benzotriazolyl carbonate esters of poly (ethylene glycol)

A Kozlowski - US Patent 6,624,246, 2003 - Google Patents
The invention provides a method for preparing a 1-benzotriazolylcarbonate ester of a water-
Soluble and non peptidic polymer by reacting a terminal hydroxyl group of a water-soluble …

Polymerizable biodegradable polymers including carbonate or dioxanone linkages

AS Sawhney, DJ Enscore, SD Goodrich… - US Patent …, 2000 - Google Patents
Water-soluble macromers including at least one hydrolysable linkage formed from
carbonate or dioxanone groups, at least one water-soluble polymeric block, and at least one …

Biosynthetic polypeptides utilizing non-naturally encoded amino acids

HS Cho, TO Daniel, AM Hays, TE Wilson… - US Patent …, 2009 - Google Patents
2005-09-12 Assigned to AMBRX, INC. reassignment AMBRX, INC. ASSIGNMENT OF
ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: HAYS, ANNA …

Method for the preparation of 1-benzotriazolyl carbonate esters of poly (ethylene glycol)

A Kozlowski - US Patent 6,710,125, 2004 - Google Patents
The invention provides a method for preparing a 1-benzotriazolylcarbonate ester of a water-
Soluble and non peptidic polymer by reacting a terminal hydroxyl group of a water-soluble …

Proteinaceous gels having visualization agents and methods of use thereof

CP Pathak - US Patent 7,211,651, 2007 - Google Patents
Proteinaceous gels having visualization agents and methods of use thereof are disclosed
herein. Further, polymeric crosslinking agents are disclosed that have an inert water soluble …

Molecular weight and functional end group control by RAFT polymerization of a bisubstituted acrylamide derivative

F D'Agosto, R Hughes, MT Charreyre, C Pichot… - …, 2003 - ACS Publications
Controlled radical polymerization of the bisubstituted acrylamide derivative N-
acryloylmorpholine (NAM) has the potential to yield telechelic polymers, one end of which …

Impact of polymer bioconjugation on protein stability and activity investigated with discrete conjugates: alternatives to PEGylation

J Morgenstern, G Gil Alvaradejo, N Bluthardt… - …, 2018 - ACS Publications
Covalent attachment of synthetic polymers to proteins, known as protein–polymer
conjugation, is currently one of the main approaches for improving the physicochemical …

Novel antigen-binding polypeptides and their uses

HS Cho, T Daniel, T Wilson, T Cujec, F Tian… - US Patent App. 11 …, 2008 - Google Patents
2008-03-04 Assigned to AMBRX, INC. reassignment AMBRX, INC. ASSIGNMENT OF
ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: HAYS, ANNA …