The proteomic analysis of human blood and blood-derived products (eg, plasma) offers an
attractive avenue to translate research progress from the laboratory into the clinic. However …

Human body fluids (biofluids) contain various proteins, some of which reflect individuals'
physiological conditions or predict diseases. Therefore, the analysis of biofluids can provide …

Growing complexity represents an issue that can be identified in various disciplines. In
system dynamics, causal loop diagrams are used for capturing dynamic nature of modelled …

Administration of first-in-class anti-EGFR monoclonal antibody cetuximab is contingent upon
extensive pharmacogenomic testing. However in addition to tumor genomics, drug exposure …

Plasma is a rich source of biomarkers with clinical relevance. However, the wide dynamic
range of protein concentration hinders the detection of low abundance proteins. Plasma …

Analysis of small biological samples would benefit from an efficient microscale fractionation
strategy that minimizes sample handling, transfer steps, and accompanying losses. Here we …

The limitations commonly observed in data-dependent acquisition (DDA) mass
spectrometric investigation of non-depleted human plasma are mainly due to the large …

Measurement of Thrombin-activatable fibrinolysis inhibitor (TAFI) in human plasma is
dependent on reproducible assays. To date, standards for measuring TAFI are frequently …

Animal welfare and stress are important issues mainly because of public perception,
marketing, product acceptance and production efficiency, quality and quantity. They are …

Retinal ganglion cell (RGC) axon regeneration in mammals can be stimulated through gene
knockouts, pharmacological agents, and biophysical stimulation. Here we present a …