Gliomas are the common type of brain tumors originating from glial cells. Epidemiologically,
gliomas occur among all ages, more often seen in adults, which males are more susceptible …

Although there are many patients with brain tumors worldwide, there are numerous
difficulties in overcoming brain tumors. Among brain tumors, glioblastoma, with a 5-year …

Background Pediatric low-grade gliomas (pLGGs) are the most common central nervous
system tumor in children, characterized by RAS/MAPK pathway driver alterations. Genomic …

Two thirds of pediatric gliomas are classified as low-grade (LGG), while in adults only
around 20% of gliomas are low-grade. However, these tumors do not only differ in their …

Gliomas are the most common and malignant primary tumors of the central nervous system
(CNS). Glioblastomas are the most malignant and aggressive form of primary brain tumors …

Glioma is easy to develop resistance to temozolomide (TMZ). TMZ-resistant glioma secretes
interleukin-10 (IL-10) and transforming growth factor-β (TGF-β), recruiting regulatory T cell …

Background The significant difference in prognosis between IDH1 wild-type and IDH1
mutant glioblastoma multiforme (GBM) may be attributed to their metabolic discrepancies …

Methods This review by Indu Bansal and Thomas E. Merchant examines the indications,
timing, and results of radiotherapy for pediatric low-grade glioma. The authors provide a …

Objective Newly emerged molecular markers in gliomas provide prognostic values beyond
the capabilities of histologic classification. BRAF mutation, especially BRAF V600E, is …

The event‐free survival of pediatric low‐grade gliomas is poor, and patients often require
multiple treatment strategies. While MEK and RAF inhibitors are efficacious in early‐phase …