Liver fibrosis due to viral or metabolic chronic liver diseases is a major challenge of global
health. Correlating with liver disease progression, fibrosis is a key factor for liver disease …

Acute decompensation (AD) of cirrhosis is defined by the development of ascites, hepatic
encephalopathy (HE) and/or variceal bleeding. Ascites is traditionally attributed to …

Alcoholic liver disease (ALD) is a complex process that includes a wide spectrum of hepatic
lesions, from steatosis to cirrhosis. Cell injury, inflammation, oxidative stress, regeneration …

In large amounts, alcohol and its metabolites can overwhelm the gastrointestinal tract (GI)
and liver and lead to damage both within the GI and in other organs. Specifically, alcohol …

Alcoholic liver disease (ALD) has been among the leading causes of cirrhosis and liver-
related death worldwide for decades. Early discoveries in alcoholic liver disease identified …

Kupffer cells are a critical component of the mononuclear phagocytic system and are central
to both the hepatic and systemic response to pathogens. Kupffer cells are reemerging as …

The selection of liver transplant candidates with hepatocellular carcinoma (HCC) relies
mostly on tumor size and number. Instead of relying on these factors, we used poor tumor …

Liver fibrosis is the excessive accumulation of extracellular matrix proteins including
collagen that occurs in most types of chronic liver diseases. Advanced liver fibrosis results in …

Chronic liver inflammation drives hepatic fibrosis, and current immunosuppressive, anti-
inflammatory, and anti-viral therapies can weaken this driver. Hepatic fibrosis is reversed …

The early detection of liver fibrosis among patients with nonalcoholic fatty liver disease
(NAFLD) is an important clinical need. In view of the suggested role played by bacterial …