More than 50 years have passed since the presentation of the Replicon Model which states
that a positively acting initiator interacts with a specific site on a circular chromosome …

In Escherichia coli, like all organisms, DNA replication is coordinated with cell cycle
progression to ensure duplication of the genome prior to cell division. Chromosome …

ATP-DnaA binds to multiple DnaA boxes in the Escherichia coli replication origin (oriC) and
forms left-half and right-half subcomplexes that promote DNA unwinding and DnaB helicase …

Chromosome replication in Escherichia coli is initiated by DnaA. DnaA binds ATP which is
essential for formation of a DnaA-oriC nucleoprotein complex that promotes strand opening …

CcrZ is a recently discovered cell cycle regulator that connects DNA replication initiation with
cell division in pneumococci and may have a similar function in related bacteria. CcrZ is also …

Regulatory inactivation of DnaA (RIDA) is one of the major regulatory mechanisms of
prokaryotic replication licensing. In RIDA, the Hda–sliding clamp complex loaded onto DNA …

The initiation of bacterial chromosomal replication is regulated by multiple pathways. To
explore novel regulators, we isolated multicopy suppressors for the cold-sensitive hda-185 Δ …

Former studies relying on hydrogen/deuterium exchange analysis suggest that DnaC bound
to DnaB alters the conformation of the N-terminal domain (NTD) of DnaB to impair the ability …

DNA replication is regulated by factors that promote or inhibit initiation. In Bacillus subtilis,
YabA is a negative regulator of DNA replication initiation while the newly identified kinase …

Expression of the Escherichia coli dnaN-encoded β clamp at≥ 10-fold higher than
chromosomally expressed levels impedes growth by interfering with DNA replication. A …