Manganese regulation of COPII condensation controls circulating lipid homeostasis

X Wang, R Huang, Y Wang, W Zhou, Y Hu, Y Yao… - Nature Cell …, 2023 - nature.com
Precise control of circulating lipids is instrumental in health and disease. Bulk lipids, carried
by specialized lipoproteins, are secreted into the circulation, initially via the coat protein …

Manganese (II) texaphyrin: a paramagnetic photoacoustic contrast agent activated by near-IR light

Y Ren, AC Sedgwick, J Chen, G Thiabaud… - Journal of the …, 2020 - ACS Publications
The NIR absorptivity of the metallotexaphyrin derivatives MMn, MGd, and MLu for
photoacoustic (PA)-based imaging is explored in this study. All three complexes …

Activating mutations in JAK2 and CALR differentially affect intracellular calcium flux in store operated calcium entry

V Bhuria, T Franz, C Baldauf, M Böttcher… - Cell Communication and …, 2024 - Springer
Abstract Background Calcium (Ca2+) signaling regulates various vital cellular functions,
including integrin activation and cell migration. Store-operated calcium entry (SOCE) via …

Targeting chronic NFAT activation with calcineurin inhibitors in diffuse large B-cell lymphoma

P Bucher, T Erdmann, P Grondona… - Blood, The Journal …, 2020 - ashpublications.org
Diffuse large B-cell lymphoma (DLBCL) represents the most common adult lymphoma and
can be divided into 2 major molecular subtypes: the germinal center B-cell-like and the …

Exploration of the effect of the alkaloid colchicine on Ca2+ handling and its related physiology in human oral cancer cells

GC Sun, HH Chen, WZ Liang, CR Jan - Archives of Oral Biology, 2019 - Elsevier
Objective: Colchicine, extracted from plants of the genus Colchicum, is a commonly
prescribed drug for inflammatory diseases. It has been shown that colchicine affected …

Identification of a selective manganese ionophore that enables nonlethal quantification of cellular manganese

KJ Horning, P Joshi, R Nitin, RC Balachandran… - Journal of Biological …, 2020 - ASBMB
Available assays for measuring cellular manganese (Mn) levels require cell lysis, restricting
longitudinal experiments and multiplexed outcome measures. Conducting a screen of small …

Ca2+ movement and cytotoxicity induced by the pyrethroid pesticide bifenthrin in human prostate cancer cells

JM Chien, WZ Liang, WC Liao… - Human & …, 2019 - journals.sagepub.com
Bifenthrin, a commonly used pyrethroid pesticide, evokes various toxicological effects in
different models. However, the effect of bifenthrin on cytosolic-free Ca2+ level ([Ca2+] i) and …

[HTML][HTML] Action of chlorzoxazone on Ca2+ movement and viability in human oral cancer cells

T Lu, WZ Liang, LJ Hao, CC Kuo, P Shieh… - Journal of Physiology …, 2019 - journals.lww.com
Chlorzoxazone is a skeletal muscle relaxant. However, the effect of chlorzoxazone on
intracellular Ca 2+ concentrations ([Ca 2+] i) in oral cancer cells is unclear. This study …

Induction of Ca2+ signaling and cytotoxic responses of human lung fibroblasts upon an antihistamine drug oxatomide treatment and evaluating the protective effects of …

WZ Liang, KW Hsieh, ZD Yang, GC Sun - Fundamental & Clinical … - Wiley Online Library
Background Oxatomide, an antihistamine drug of the diphenylmethylpiperazine family, has
anti‐inflammatory effects in airway disease. Because oxatomide was shown to cause …

Señal de calcio y secreción de miocinas en el músculo esquelético humano durante el envejecimiento

B Calle Ciborro - 2023 - dehesa.unex.es
La contracción del músculo esquelético libera numerosos factores endocrinos
denominados miocinas. La IL-6 es una de las principales miocinas debido a sus efectos …