Cellular senescence is a state of stable, terminal cell cycle arrest associated with various
macromolecular changes and a hypersecretory, pro-inflammatory phenotype. Entry of cells …

Loss of cell cycle control is characteristic of tumorigenesis. The protein p21 is the founding
member of cyclin-dependent kinase inhibitors and an important versatile cell cycle protein …

For the past two decades, cellular senescence has been recognized as a central component
of the tumor cell response to chemotherapy and radiation. Traditionally, this form of …

Several cancer interventions induce DNA damage and promote senescence in cancer and
nonmalignant cells. Senescent cells secrete a collection of proinflammatory factors …

Cellular senescence is a response to nonlethal stress that results in persistent cytostasis
with a distinct morphological and biochemical phenotype. The senescence phenotype …

Abstract Nuclear DNA topoisomerase I (TOP1) is an essential human enzyme. It is the only
known target of the alkaloid camptothecin, from which the potent anticancer agents …

The main goal when treating malignancies with radiation therapy is to deprive tumor cells of
their reproductive potential. One approach to achieve this is by inducing tumor cell …

To date, dozens of stress‐induced cellular senescence phenotypes have been reported.
These cellular senescence states may differ substantially from each other, as well as from …

Cell senescence is broadly defined as the physiological program of terminal growth arrest,
which can be triggered by alterations of telomeres or by different forms of stress. Neoplastic …

Chemotherapy is designed to induce cell death. However, at non-lethal doses, cancer cells
can choose to remain proliferative or become senescent. The slow development of …