In mammals, hundreds of proteins use iron in a multitude of cellular functions, including vital
processes such as mitochondrial respiration, gene regulation and DNA synthesis or repair …

Parkinson's disease (PD) is characterized by dopaminergic (DA) neuron loss and the
formation of cytoplasmic protein inclusions. Although the exact pathogenesis of PD is …

Hepatocytes have important roles in liver iron homeostasis, abnormalities in which are
tightly associated with liver steatosis and fibrosis. Here, we show that non-alcoholic fatty liver …

Iron is biologically essential, but also potentially toxic; as such it is tightly controlled at cell
and systemic levels to prevent both deficiency and overload. Iron regulatory proteins post …

Abstract Iron deficiency anemia affects> 1.2 billions individuals worldwide, and iron
deficiency in the absence of anemia is even more frequent. Total-body (absolute) iron …

Ferroptosis, regulated cell death characterized by the iron-dependent accumulation of lethal
lipid reactive oxygen species, contributes to tissue homeostasis and numerous pathologies …

Anemia of Inflammation Anemia of inflammation is a common normocytic, normochromic
anemia associated with systemic inflammation that increases the level of hepcidin and …

Iron is an essential micronutrient for virtually all living cells. In infectious diseases, both
invading pathogens and mammalian cells including those of the immune system require iron …

Iron is an essential element required by cells and has been described as a key player in
ferroptosis. Ferritin operates as a fundamental iron storage protein in cells forming …

The control over iron availability is crucial under homeostatic conditions and even more in
the case of an infection. This results from diverse properties of iron: first, iron is an important …