[HTML][HTML] WNT/β-catenin signaling in the development of liver cancers

S He, S Tang - Biomedicine & Pharmacotherapy, 2020 - Elsevier
The WNT/β-catenin signaling pathway is a highly conserved and tightly controlled molecular
mechanism that regulates embryonic development, cellular proliferation and differentiation …

WNT signaling in melanoma

A Gajos-Michniewicz, M Czyz - International journal of molecular sciences, 2020 - mdpi.com
WNT-signaling controls important cellular processes throughout embryonic development
and adult life, so any deregulation of this signaling can result in a wide range of pathologies …

Pan-cancer image-based detection of clinically actionable genetic alterations

JN Kather, LR Heij, HI Grabsch, C Loeffler, A Echle… - Nature cancer, 2020 - nature.com
Molecular alterations in cancer can cause phenotypic changes in tumor cells and their
microenvironment. Routine histopathology tissue slides, which are ubiquitously available …

Targeting cancer associated fibroblasts in liver fibrosis and liver cancer using nanocarriers

L Kaps, D Schuppan - Cells, 2020 - mdpi.com
Cancer associated fibroblasts (CAF) and the extracellular matrix (ECM) produced by them
have been recognized as key players in cancer biology and emerged as important targets …

Pathogenesis and current treatment strategies of hepatocellular carcinoma

D Tümen, P Heumann, K Gülow, CN Demirci… - Biomedicines, 2022 - mdpi.com
Hepatocellular carcinoma (HCC) is the most frequent liver cancer with high lethality and low
five-year survival rates leading to a substantial worldwide burden for healthcare systems …

Mangifera indica (Mango): A Promising Medicinal Plant for Breast Cancer Therapy and Understanding Its Potential Mechanisms of Action

KM Yap, M Sekar, LJ Seow, SH Gan… - … Cancer: Targets and …, 2021 - Taylor & Francis
Globally, breast cancer is the most common cancer type and is one of the most significant
causes of deaths in women. To date, multiple clinical interventions have been applied …

Human amniotic mesenchymal stem cells and their paracrine factors promote wound healing by inhibiting heat stress-induced skin cell apoptosis and enhancing their …

JY Li, KK Ren, WJ Zhang, L Xiao, HY Wu… - Stem cell research & …, 2019 - Springer
Background Increasing evidence has shown that mesenchymal stem cells (MSCs) yield a
favorable therapeutic benefit for thermal burn skin wounds. Human amniotic MSCs …

KIF2C: a novel link between Wnt/β-catenin and mTORC1 signaling in the pathogenesis of hepatocellular carcinoma

S Wei, M Dai, C Zhang, K Teng, F Wang, H Li… - Protein & …, 2021 - academic.oup.com
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and is the
fourth-leading cause of cancer-related deaths worldwide. HCC is refractory to many …

Rutin (Bioflavonoid) as cell signaling pathway modulator: Prospects in treatment and chemoprevention

P Pandey, F Khan, HA Qari, M Oves - Pharmaceuticals, 2021 - mdpi.com
Cancer is a complex ailment orchestrated by numerous intrinsic and extrinsic pathways.
Recent research has displayed a deep interest in developing plant-based cancer …

Aberrant lipid metabolism in hepatocellular carcinoma cells as well as immune microenvironment: a review

B Hu, JZ Lin, XB Yang, XT Sang - Cell proliferation, 2020 - Wiley Online Library
Hepatocellular carcinoma (HCC) is a primary malignancy of the liver with a high worldwide
prevalence and poor prognosis. Researches are urgently needed on its molecular …