Obesity is considered an important factor for many chronic diseases, including diabetes,
cardiovascular disease and cancer. The expansion of adipose tissue in obesity is due to an …

Fibroblast growth factor 8 (Fgf8) is a secreted signaling protein expressed in numerous
temporospatial domains that are potentially relevant to cardiovascular development …

TOPK (T–lymphokine-activated killer cell–originated protein kinase) is highly and frequently
transactivated in various cancer tissues, including lung and triple-negative breast cancers …

Although esophageal squamous cell carcinoma (ESCC) is one of the most lethal cancers,
there are major bottlenecks in its therapeutic approaches, primarily the identification of …

Basal-like breast cancers (BLBCs) are aggressive breast cancers associated with poor
survival. Defining the key drivers of BLBC growth will allow identification of molecules for …

Mammalian target of rapamycin (mTOR)-directed eukaryotic translation initiation factor 4E-
binding protein 1 (4E-BP1) phosphorylation promotes cap-dependent translation and …

Mitochondria are essential for energy production and although they have their own genome,
many nuclear-encoded mitochondrial ribosomal proteins (MRPs) are required for proper …

The mammalian egg employs a wide spectrum of epigenome modification machinery to
reprogram the sperm nucleus shortly after fertilization. This event is required for …

Replication stress, a major cause of genome instability in cycling cells, is mainly prevented
by the ATR‐dependent replication stress response pathway in somatic cells. However, the …

Background Skull diversity in the neotropical leaf-nosed bats (Phyllostomidae) evolved
through a heterochronic process called peramorphosis, with underlying causes varying by …