[HTML][HTML] Type I and type III interferons–induction, signaling, evasion, and application to combat COVID-19

A Park, A Iwasaki - Cell host & microbe, 2020 - cell.com
Coronavirus disease 2019 (COVID-19) is a global pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). Without approved antiviral therapeutics …

MERS, SARS and other coronaviruses as causes of pneumonia

Y Yin, RG Wunderink - Respirology, 2018 - Wiley Online Library
Human coronaviruses (HCoVs) have been considered to be relatively harmless respiratory
pathogens in the past. However, after the outbreak of the severe acute respiratory syndrome …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 signaling

Y Zheng, MW Zhuang, L Han, J Zhang… - Signal transduction and …, 2020 - nature.com
Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has quickly spread worldwide and has affected …

Remdesivir inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice

AJ Pruijssers, AS George, A Schäfer, SR Leist… - Cell reports, 2020 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the novel viral disease COVID-19. With no approved therapies, this pandemic illustrates the …

Vascular disease and thrombosis in SARS-CoV-2-infected rhesus macaques

M Aid, K Busman-Sahay, SJ Vidal, Z Maliga, S Bondoc… - Cell, 2020 - cell.com
The COVID-19 pandemic has led to extensive morbidity and mortality throughout the world.
Clinical features that drive SARS-CoV-2 pathogenesis in humans include inflammation and …

[HTML][HTML] Transcriptomic profiling of SARS-CoV-2 infected human cell lines identifies HSP90 as target for COVID-19 therapy

E Wyler, K Mösbauer, V Franke, A Diag, LT Gottula… - IScience, 2021 - cell.com
Detailed knowledge of the molecular biology of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection is crucial for understanding of viral replication, host …

[HTML][HTML] SARS-CoV-2 suppresses IFNβ production mediated by NSP1, 5, 6, 15, ORF6 and ORF7b but does not suppress the effects of added interferon

M Shemesh, TE Aktepe, JM Deerain, JL McAuley… - PLoS …, 2021 - journals.plos.org
Type I Interferons (IFN-Is) are a family of cytokines which play a major role in inhibiting viral
infection. Resultantly, many viruses have evolved mechanisms in which to evade the IFN-I …

Master regulator analysis of the SARS-CoV-2/human interactome

PH Guzzi, D Mercatelli, C Ceraolo… - Journal of clinical medicine, 2020 - mdpi.com
The recent epidemic outbreak of a novel human coronavirus called SARS-CoV-2 causing
the respiratory tract disease COVID-19 has reached worldwide resonance and a global …

[HTML][HTML] A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence

VD Menachery, BL Yount, K Debbink, S Agnihothram… - Nature medicine, 2015 - nature.com
The emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle
East respiratory syndrome (MERS)-CoV underscores the threat of cross-species …

[HTML][HTML] Eicosanoid signalling blockade protects middle-aged mice from severe COVID-19

LYR Wong, J Zheng, K Wilhelmsen, K Li, ME Ortiz… - Nature, 2022 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) is especially severe in aged populations.
Vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are …