Skeletal metastases are frequent complications of many cancers, causing bone
complications (fractures, bone pain, disability) that negatively affect the patient's quality of …

Abstract MicroRNAs (miRNAs), short, highly conserved non-coding RNA, influence gene
expression by sequential mechanisms such as mRNA breakdown or translational …

Mesenchymal stem cells (MSCs) have been identified in many adult tissues. MSCs can
regenerate through cell division or differentiate into adipocytes, osteoblasts and …

MicroRNAs have an important role in bone homeostasis. However, the detailed mechanism
of microRNA-mediated intercellular communication between bone cells remains elusive …

Microvesicle-and exosome-mediated transport of microRNAs (miRNAs) represents a novel
cellular and molecular pathway for cell–cell communication. In this study, we tested the …

MicroRNAs (miRNAs) are found in the circulatory biofluids considering the important
molecules for biomarker study in aging and age-related diseases. Blood or blood …

Context: Established bone turnover markers do not reflect fracture risk in idiopathic male and
premenopausal osteoporosis and the role of microRNAs (miRNAs) in these patients is …

Biomarkers are essential tools in clinical research and practice. Useful biomarkers must
combine good measurability, validated association with biological processes or outcomes …

Osteoporosis is the consequence of altered bone metabolism resulting in the systemic
reduction of bone strength and increased risk of fragility fractures. MicroRNAs (miRNAs) …

Cells sense mechanical cues from the extracellular matrix to regulate cellular behavior and
maintain tissue homeostasis. The nucleus has been implicated as a key mechanosensor …