Molecular oxygen (O2) is essential for most biological reactions in mammalian cells. When
the intracellular oxygen content decreases, it is called hypoxia. The process of hypoxia is …

The involvement of inflammasomes in the proinflammatory response observed in chronic
liver diseases, such as alcohol-associated liver disease (ALD) and nonalcoholic fatty liver …

Ferroptosis, a newly discovered form of regulated cell death, is emerging as a promising
approach to tumor therapy. However, the spatiotemporal control of cell-intrinsic Fenton …

The pathogenetic mechanism of contrast-induced acute kidney injury (CI-AKI), which is the
third most common cause of hospital-acquired AKI, has not been elucidated. Previously, we …

Adipose tissue macrophage (ATM) inflammation is involved with meta-inflammation and
pathology of metabolic complications. Here we report that in adipocytes, elevated lactate …

Ferroptosis is a new form of regulated cell death. Several studies have demonstrated that
ferroptosis was involved in multiple diseases. However, the precise role of ferroptosis in …

Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver disease worldwide, and
a major cause of liver cirrhosis and hepatocellular carcinoma. NAFLD is intimately linked …

Non-alcoholic fatty liver disease (NAFLD) comprises fatty liver (steatosis), non-alcoholic
steatohepatitis (NASH) and fibrosis/cirrhosis and may lead to end-stage liver failure or …

Aberrant hepatocyte Notch activity is critical to the development of nonalcoholic
steatohepatitis (NASH)–induced liver fibrosis, but mechanisms underlying Notch reactivation …

The present review is a summary of the recent literature concerning Bnip3 expression,
function, and regulation, along with its implications in mitochondrial dysfunction, disorders of …