[HTML][HTML] The role of M1/M2 macrophage polarization in rheumatoid arthritis synovitis

M Cutolo, R Campitiello, E Gotelli… - Frontiers in …, 2022 - frontiersin.org
Innate and adaptive immunity represent a harmonic counterbalanced system involved in the
induction, progression, and possibly resolution of the inflammatory reaction that characterize …

Contribution of monocytes and macrophages to the local tissue inflammation and cytokine storm in COVID-19: Lessons from SARS and MERS, and potential …

A Jafarzadeh, P Chauhan, B Saha, S Jafarzadeh… - Life sciences, 2020 - Elsevier
Abstract The COVID-19-, SARS-and MERS-related coronaviruses share many genomic and
structural similarities. However, the SARS-CoV-2 is less pathogenic than SARS-CoV and …

[HTML][HTML] Macrophage-osteoclast associations: origin, polarization, and subgroups

Y Sun, J Li, X Xie, F Gu, Z Sui, K Zhang… - Frontiers in …, 2021 - frontiersin.org
Cellular associations in the bone microenvironment are involved in modulating the balance
between bone remodeling and resorption, which is necessary for maintaining a normal bone …

pH/NIR-responsive and self-healing coatings with bacteria killing, osteogenesis, and angiogenesis performances on magnesium alloy

Y Zhao, P He, J Yao, M Li, B Wang, L Han, Z Huang… - Biomaterials, 2023 - Elsevier
Although biodegradable polymer coatings can impede corrosion of magnesium (Mg)-based
orthopedic implants, they are prone to excessive degradation and accidental scratching in …

[HTML][HTML] CCL2/CCR2 signaling in cancer pathogenesis

Q Hao, JV Vadgama, P Wang - Cell Communication and Signaling, 2020 - Springer
Chemokines are a family of small cytokines, which guide a variety of immune/inflammatory
cells to the site of tumor in tumorigenesis. A dysregulated expression of chemokines is …

[HTML][HTML] Molecular and cellular heterogeneity in rheumatoid arthritis: mechanisms and clinical implications

J Zhao, S Guo, SJ Schrodi, D He - Frontiers in immunology, 2021 - frontiersin.org
Rheumatoid arthritis is an autoimmune disease that exhibits significant clinical
heterogeneity. There are various treatments for rheumatoid arthritis, including disease …

Transport by circulating myeloid cells drives liposomal accumulation in inflamed synovium

J Deprez, R Verbeke, S Meulewaeter, I Aernout… - Nature …, 2023 - nature.com
The therapeutic potential of liposomes to deliver drugs into inflamed tissue is well
documented. Liposomes are believed to largely transport drugs into inflamed joints by …

[HTML][HTML] Cellular and molecular pathways of COVID-19 and potential points of therapeutic intervention

JP Hussman - Frontiers in pharmacology, 2020 - frontiersin.org
With the objective of linking early findings relating to the novel SARS-CoV-2 coronavirus
with potentially informative findings from prior research literature and to promote …

[HTML][HTML] Critical role of synovial tissue–resident macrophage and fibroblast subsets in the persistence of joint inflammation

S Kemble, AP Croft - Frontiers in immunology, 2021 - frontiersin.org
Rheumatoid arthritis (RA) is a chronic prototypic immune-mediated inflammatory disease
which is characterized by persistent synovial inflammation, leading to progressive joint …

[HTML][HTML] MicroRNA-mediated epigenetic regulation of rheumatoid arthritis susceptibility and pathogenesis

C Chang, L Xu, R Zhang, Y Jin, P Jiang, K Wei… - Frontiers in …, 2022 - frontiersin.org
MicroRNAs (miRNAs) play crucial roles in regulating the transcriptome and development of
rheumatoid arthritis (RA). Currently, a comprehensive map illustrating how miRNAs regulate …