Multiple myeloma in the marrow: pathogenesis and treatments

H Fairfield, C Falank, L Avery… - Annals of the New York …, 2016 - Wiley Online Library
Multiple myeloma (MM) is a B cell malignancy resulting in osteolytic lesions and fractures. In
the disease state, bone healing is limited owing to increased osteoclastic and decreased …

Epidemiology of multiple myeloma

N Becker - Multiple myeloma, 2011 - Springer
Multiple myelomas are a less frequent cancer site among both sexes. On a worldwide scale,
it is estimated that about 86 000 incident cases occur annually, accounting for about 0.8% of …

Multiple myeloma: a review of the epidemiologic literature

DD Alexander, PJ Mink, HO Adami… - … journal of cancer, 2007 - Wiley Online Library
Multiple myeloma, a neoplasm of plasma cells, accounts for∼∼ 15% of
lymphatohematopoietic cancers (LHC) and 2% of all cancers in the US. Incidence rates …

Acetyl-CoA synthetase 2: a critical linkage in obesity-induced tumorigenesis in myeloma

Z Li, H Liu, J He, Z Wang, Z Yin, G You, Z Wang… - Cell metabolism, 2021 - cell.com
Obesity is often linked to malignancies including multiple myeloma, and the underlying
mechanisms remain elusive. Here we showed that acetyl-CoA synthetase 2 (ACSS2) may …

Economic costs of obesity

GA Colditz - The American journal of clinical nutrition, 1992 - Elsevier
Approximately 34 million US adults were obese in 1980. Obesity is associated with
increased risk of non-insulin-dependent diabetes mellitus (NIDDM), hypertension …

Racial disparities in the prevalence of monoclonal gammopathies: a population-based study of 12 482 persons from the national health and nutritional examination …

O Landgren, BI Graubard, JA Katzmann, RA Kyle… - Leukemia, 2014 - nature.com
Multiple myeloma (MM) incidence is markedly higher in blacks compared with whites, which
may be related to a higher prevalence of monoclonal gammopathy of undetermined …

Body mass index and risk of multiple myeloma: a meta-analysis of prospective studies

A Wallin, SC Larsson - European journal of cancer, 2011 - Elsevier
Excess body weight has been identified as a risk factor for various cancer types. Since the
publication of two meta-analyses indicating that body mass index (BMI) is positively …

Obesity and the risk for a hematological malignancy: leukemia, lymphoma, or myeloma

MA Lichtman - The oncologist, 2010 - academic.oup.com
The aggregate of epidemiological studies indicates a significantly elevated risk for cancer in
people with a high body mass index (BMI); a “dose–response” effect exists with increasing …

Prevalence of myeloma precursor state monoclonal gammopathy of undetermined significance in 12372 individuals 10–49 years old: a population-based study from …

O Landgren, BI Graubard, S Kumar, RA Kyle… - Blood cancer …, 2017 - nature.com
We studied the prevalence of monoclonal gammopathy of undetermined significance
(MGUS) in younger individuals, age 10–49 years, using samples from the National Health …

Epidemiology of the plasma-cell disorders

RA Kyle, SV Rajkumar - Best practice & research Clinical haematology, 2007 - Elsevier
This review of the plasma-cell disorders begins with the definition of monoclonal
gammopathy of undetermined significance (MGUS). The prevalence of MGUS in white and …