[HTML][HTML] Migrastatics—anti-metastatic and anti-invasion drugs: promises and challenges

A Gandalovičová, D Rosel, M Fernandes, P Veselý… - Trends in cancer, 2017 - cell.com
In solid cancers, invasion and metastasis account for more than 90% of mortality. However,
in the current armory of anticancer therapies, a specific category of anti-invasion and …

[HTML][HTML] Targeting the Hippo pathway for breast cancer therapy

L Wu, X Yang - Cancers, 2018 - mdpi.com
Breast cancer (BC) is one of the most prominent diseases in the world, and the treatments
for BC have many limitations, such as resistance and a lack of reliable biomarkers. Currently …

Targeting the cytoskeleton against metastatic dissemination

C Ruggiero, E Lalli - Cancer and Metastasis Reviews, 2021 - Springer
Cancer is a pathology characterized by a loss or a perturbation of a number of typical
features of normal cell behaviour. Indeed, the acquisition of an inappropriate migratory and …

Gold from the sea: marine compounds as inhibitors of the hallmarks of cancer

M Schumacher, M Kelkel, M Dicato, M Diederich - Biotechnology advances, 2011 - Elsevier
Cancer is one of the most deadly diseases in the world. Although advances in the field of
chemo-preventive and therapeutic medicine have been made regularly over the last ten …

[HTML][HTML] Propagation of THz irradiation energy through aqueous layers: Demolition of actin filaments in living cells

S Yamazaki, M Harata, Y Ueno, M Tsubouchi… - Scientific reports, 2020 - nature.com
The effect of terahertz (THz) radiation on deep tissues of human body has been considered
negligible due to strong absorption by water molecules. However, we observed that the …

[HTML][HTML] Actin polymerization is activated by terahertz irradiation

S Yamazaki, M Harata, T Idehara, K Konagaya… - Scientific Reports, 2018 - nature.com
Polymerization of monomeric actin into filaments has pivotal roles in cell motility, growth,
differentiation, and gene expression. Therefore, techniques of manipulating actin …

Optical Control of G-Actin with a Photoswitchable Latrunculin

NA Veprek, MH Cooper, L Laprell… - Journal of the …, 2024 - ACS Publications
Actin is one of the most abundant proteins in eukaryotic cells and is a key component of the
cytoskeleton. A range of small molecules has emerged that interfere with actin dynamics by …

[HTML][HTML] Collective locomotion of human cells, wound healing and their control by extracts and isolated compounds from marine invertebrates

C Luparello, M Mauro, V Lazzara, M Vazzana - Molecules, 2020 - mdpi.com
The collective migration of cells is a complex integrated process that represents a common
theme joining morphogenesis, tissue regeneration, and tumor biology. It is known that a …

[HTML][HTML] Exploiting the cytoskeletal filaments of neoplastic cells to potentiate a novel therapeutic approach

M Trendowski - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2014 - Elsevier
Although cytoskeletal-directed agents have been a mainstay in chemotherapeutic protocols
due to their ability to readily interfere with the rapid mitotic progression of neoplastic cells …

A rapid biofabrication technique for self-assembled collagen-based multicellular and heterogeneous 3D tissue constructs

A Shahin-Shamsabadi, PR Selvaganapathy - Acta biomaterialia, 2019 - Elsevier
Although monolayer cell culture models are considered as gold standard for in vitro
modeling of pathophysiological events, they cannot reconstruct in vivo like gradient of gases …