Phytochemicals from medicinal plants from African forests with potentials in rheumatoid arthritis management
Objectives Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease
characterized by inflammation, pain, and cartilage and bone damage. There is currently no …
characterized by inflammation, pain, and cartilage and bone damage. There is currently no …
The acute anti-inflammatory action of xylopic acid isolated from Xylopia aethiopica
Background Our earlier studies had given evidence of the traditional application of Xylopia
aethiopica in the management of inflammation. The principal constituent obtained from its …
aethiopica in the management of inflammation. The principal constituent obtained from its …
Kauranes as anti-inflammatory and immunomodulatory agents: an overview of in vitro and in vivo effects
MR Mijares, GP Martínez, JB De Sanctis - Plant Secondary Metabolites …, 2022 - Springer
Natural products have been used for the prevention and treatment of various pathologies,
including acute and chronic inflammatory diseases, autoimmune diseases, and cancer …
including acute and chronic inflammatory diseases, autoimmune diseases, and cancer …
Evidence of an antidepressant-like effect of xylopic acid mediated by serotonergic mechanisms
Background Depression causes significant debilitating symptoms and economic burden.
Current management is challenged by slow onset of action and modest efficacies of …
Current management is challenged by slow onset of action and modest efficacies of …
Antiinflammatory properties of betulinic acid and xylopic acid in the carrageenan‐induced pleurisy model of lung inflammation in mice
This study investigated the antiinflammatory properties of betulinic acid (BA) and xylopic
acid (XA) extracted from Margaritaria discoidea and Xylopia aethiopica, respectively. M …
acid (XA) extracted from Margaritaria discoidea and Xylopia aethiopica, respectively. M …
Regulation of Nrf2 and NF-κB activities may contribute to the anti-inflammatory mechanism of xylopic acid
Xylopic acid (XA) is a kaurene diterpene which naturally exists in African plants such as
Xylopia aethiopica. It has been established to exhibit acute and chronic anti-inflammatory …
Xylopia aethiopica. It has been established to exhibit acute and chronic anti-inflammatory …
[HTML][HTML] Potential effects of xylopic acid on acetic acid-induced ulcerative colitis in rats
Materials and Methods We investigated the effect of XA on body weight, disease activity,
inflammatory cell infiltration, and generation of reactive oxygen species. Rats were treated …
inflammatory cell infiltration, and generation of reactive oxygen species. Rats were treated …
Investigation of Herb‐Drug Interactions between Xylopia aethiopica, Its Principal Constituent Xylopic Acid, and Antidepressants
CC Ndu, WKM Abotsi, PK Mante - … in Pharmacological and …, 2024 - Wiley Online Library
Introduction. Depression affects an estimated 350 million people worldwide and is
implicated in up to 60% of suicides. Only about 60–70% of patients respond to …
implicated in up to 60% of suicides. Only about 60–70% of patients respond to …
[HTML][HTML] Xylopic acid-amodiaquine and xylopic acid-artesunate combinations are effective in managing malaria in Plasmodium berghei-infected mice
Abstract Background Evidence of Plasmodium resistance to some of the current anti-
malarial agents makes it imperative to search for newer and effective drugs to combat …
malarial agents makes it imperative to search for newer and effective drugs to combat …
Cutaneous and systemic anti-allergic potential of xylopic acid in rodents
Xylopic acid is a kaurene diterpene isolated from the dried fruit of Xylopia aethiopica. It has
been identified to exhibit analgesic activity and also demonstrates acute and chronic anti …
been identified to exhibit analgesic activity and also demonstrates acute and chronic anti …