Systematic identification of gene combinations to target in innate immune cells to enhance T cell activation

L Xia, A Komissarova, A Jacover, Y Shovman… - Nature …, 2023 - nature.com
Genetic engineering of immune cells has opened new avenues for improving their
functionality but it remains a challenge to pinpoint which genes or combination of genes are …

Prognostic cellular senescence-related lncRNAs patterns to predict clinical outcome and immune response in colon cancer

L Cao, F Chen, L Xu, J Zeng, Y Wang, S Zhang… - Frontiers in …, 2024 - frontiersin.org
Background Cellular senescence (CS) is believed to be a major factor in the evolution of
cancer. However, CS-related lncRNAs (CSRLs) involved in colon cancer regulation are not …

INHBA gene silencing inhibits proliferation, migration, and invasion of osteosarcoma cells by repressing TGF-β signaling pathway activation

H Zhang, Y Huang, Q Wen, Y Li, L Guo… - Journal of Orthopaedic …, 2023 - Springer
Background Osteosarcoma (OS) is a refractory malignancy. This study aimed to explore the
roles and mechanisms of Inhibin subunit beta A (INHBA) in OS. Methods INHBA expression …

Mapping cellular senescence networks in human diabetic foot ulcers

GT Yu, DD Monie, S Khosla, T Tchkonia, JL Kirkland… - GeroScience, 2024 - Springer
Cellular senescence, a cell fate defined by irreversible cell cycle arrest, has been observed
to contribute to chronic age-related conditions including non-healing wounds, such as …

Using Machine Learning Methods to Study Colorectal Cancer Tumor Micro-Environment and Its Biomarkers

W Wei, Y Li, T Huang - International Journal of Molecular Sciences, 2023 - mdpi.com
Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide, and the
identification of biomarkers can improve early detection and personalized treatment. In this …

Correlation of INHBA overexpression with pathological features, antitumor immune response and clinical prognosis in cervical cancer

L Zeng, X Sun - Medicina, 2023 - mdpi.com
Background and Objectives: Cervical cancer (CC) is a malignant tumor occurring in the
cervical epithelium, which is one of the most common cancer-caused deaths in females …

Discovery of PELATON links to the INHBA gene in the TGF-β pathway in colorectal cancer using a combination of bioinformatics and experimental investigations

M Abutalebi, D Li, W Ahmad, K Mokhtari… - International Journal of …, 2024 - Elsevier
Colorectal cancer (CRC) is a major worldwide health issue, with high rates of both
occurrence and mortality. Dysregulation of the transforming growth factor-beta (TGF-β) …

Identification and Validation of Serum Biomarkers to Improve Colorectal Cancer Diagnosis

ML Yoon, H Chun, HJ Lee, WJ Seo, JY Lee… - Cancer …, 2024 - Wiley Online Library
Background The pressing need for reliable biomarkers in colorectal cancer (CRC) diagnosis
and prognosis is a major global health concern. Current diagnostic methods rely heavily on …

HOXC6: A promising biomarker linked to an immunoevasive microenvironment in colorectal cancer based on TCGA analysis and cohort validation

M Weng, Y Lai, X Ge, W Gu, X Zhang, L Li, M Sun - Heliyon, 2024 - cell.com
HOXC6 plays an essential part of the carcinogenesis of solid tumors, but its functional
relevance within the immune contexture in patients with colorectal cancer (CRC) is still …

INHBA regulates Hippo signaling to confer 5-FU chemoresistance mediated by cellular senescence in colon cancer cells

Z Zhang, L Chen, Q Yang, X Tang, J Li, G Zhang… - … International Journal of …, 2024 - Elsevier
Colon cancer has become a global public health challenge, and 5-Fluorouracil (5-FU)
chemoresistance is a major obstacle in its treatment. Chemoresistance can be mediated by …