[4+ 2]-Cycloadditions are increasingly being recognized in the biosynthetic pathways of
many structurally complex natural products. A relatively small collection of enzymes from …

Covering: 1997 to early 2003 Recent studies on enzymes catalyzing the Diels–Alder
reaction, often named “Diels–Alderases”, clearly demonstrated the involvement of this …

Abstract The Diels–Alder reaction is a [4+ 2] cycloaddition reaction in which a cyclohexene
ring is formed between a 1, 3-diene and an electron-deficient alkene via a single pericyclic …

Abstract The Diels–Alder reaction, which forms a six-membered ring from an alkene
(dienophile) and a 1, 3-diene, is synthetically very useful for construction of cyclic products …

Eight examples of biosynthetic pathways wherein a natural enzyme has been identified and
claimed to function as a catalyst for the [4+ 2] cycloaddition reaction, namely, Diels …

Covering: 2000 to 2018 Pericyclic reactions are a distinct class of reactions that have wide
synthetic utility. Before the recent discoveries described in this review, enzyme-catalyzed …

The solanapyrone biosynthetic gene cluster was cloned from Alternaria solani. It consists of
six genes—sol1–6—coding for a polyketide synthase, an O‐methyltransferase, a …

Covering: up to mid-2014 Over the last several decades, the number of pharmacologically
active natural products has significantly increased and several natural product families have …

Rhizocticins are phosphonate oligopeptide antibiotics containing the C-terminal
nonproteinogenic amino acid (Z)-l-2-amino-5-phosphono-3-pentenoic acid (APPA). Here we …

The antibiotic kijanimicin produced by the actinomycete Actinomadura kijaniata has a broad
spectrum of bioactivities as well as a number of interesting biosynthetic features. To …