[HTML][HTML] Blood-brain barrier: from physiology to disease and back
MD Sweeney, Z Zhao, A Montagne… - Physiological …, 2018 - journals.physiology.org
The blood-brain barrier (BBB) prevents neurotoxic plasma components, blood cells, and
pathogens from entering the brain. At the same time, the BBB regulates transport of …
pathogens from entering the brain. At the same time, the BBB regulates transport of …
Bidirectional relationship between sleep and Alzheimer's disease: role of amyloid, tau, and other factors
C Wang, DM Holtzman - Neuropsychopharmacology, 2020 - nature.com
As we age, we experience changes in our nighttime sleep and daytime wakefulness.
Individuals afflicted with Alzheimer's disease (AD) can develop sleep problems even before …
Individuals afflicted with Alzheimer's disease (AD) can develop sleep problems even before …
The amyloid hypothesis of Alzheimer's disease at 25 years
Despite continuing debate about the amyloid β‐protein (or Aβ hypothesis, new lines of
evidence from laboratories and clinics worldwide support the concept that an imbalance …
evidence from laboratories and clinics worldwide support the concept that an imbalance …
The cellular phase of Alzheimer's disease
B De Strooper, E Karran - Cell, 2016 - cell.com
The amyloid hypothesis for Alzheimer's disease (AD) posits a neuron-centric, linear cascade
initiated by Aβ and leading to dementia. This direct causality is incompatible with clinical …
initiated by Aβ and leading to dementia. This direct causality is incompatible with clinical …
Aβ profiles generated by Alzheimer's disease causing PSEN1 variants determine the pathogenicity of the mutation and predict age at disease onset
D Petit, SG Fernández, KM Zoltowska, T Enzlein… - Molecular …, 2022 - nature.com
Familial Alzheimer's disease (FAD), caused by mutations in Presenilin (PSEN1/2) and
Amyloid Precursor Protein (APP) genes, is associated with an early age at onset (AAO) of …
Amyloid Precursor Protein (APP) genes, is associated with an early age at onset (AAO) of …
The substrate repertoire of γ-secretase/presenilin
G Güner, SF Lichtenthaler - Seminars in cell & developmental biology, 2020 - Elsevier
The intramembrane protease γ-secretase is a hetero-tetrameric protein complex with
presenilin as the catalytic subunit and cleaves its membrane protein substrates within their …
presenilin as the catalytic subunit and cleaves its membrane protein substrates within their …
The amyloid cascade hypothesis: are we poised for success or failure?
E Karran, B De Strooper - Journal of neurochemistry, 2016 - Wiley Online Library
The first description of Alzheimer's disease (AD) was made in 1907 by Alois Alzheimer
(Allgemeine Zeitschrift fur Psyciatrie und Psychisch‐Gerichtliche Medizin 64, 3, 1907) …
(Allgemeine Zeitschrift fur Psyciatrie und Psychisch‐Gerichtliche Medizin 64, 3, 1907) …
Alzheimer's-causing mutations shift Aβ length by destabilizing γ-secretase-Aβn interactions
M Szaruga, B Munteanu, S Lismont, S Veugelen… - Cell, 2017 - cell.com
Summary Alzheimer's disease (AD)-linked mutations in Presenilins (PSEN) and the amyloid
precursor protein (APP) lead to production of longer amyloidogenic Aβ peptides. The shift in …
precursor protein (APP) lead to production of longer amyloidogenic Aβ peptides. The shift in …
Clinical phenotype and genetic associations in autosomal dominant familial Alzheimer's disease: a case series
Background The causes of phenotypic heterogeneity in familial Alzheimer's disease with
autosomal dominant inheritance are not well understood. We aimed to characterise clinical …
autosomal dominant inheritance are not well understood. We aimed to characterise clinical …
Past, present and future role of retinal imaging in neurodegenerative disease
AH Kashani, S Asanad, JW Chan, MB Singer… - Progress in retinal and …, 2021 - Elsevier
Retinal imaging technology is rapidly advancing and can provide ever-increasing amounts
of information about the structure, function and molecular composition of retinal tissue in …
of information about the structure, function and molecular composition of retinal tissue in …