Real-time PCR applications for diagnosis of leishmaniasis

L Galluzzi, M Ceccarelli, A Diotallevi, M Menotta… - Parasites & vectors, 2018 - Springer
Leishmaniasis is a vector-borne disease caused by many Leishmania species, which can
infect both humans and other mammals. Leishmaniasis is a complex disease, with …

An approach for interlaboratory comparison of conventional and real-time PCR assays for diagnosis of human leishmaniasis

I Cruz, A Millet, E Carrillo, M Chenik, P Salotra… - Experimental …, 2013 - Elsevier
Protozoa of the Leishmania genus are transmitted to humans by the bite of infected
sandflies, and are the causative agents of leishmaniasis which ranges from cutaneous to …

Novel CRISPR-based detection of Leishmania species

E Dueñas, JA Nakamoto, L Cabrera-Sosa… - Frontiers in …, 2022 - frontiersin.org
Tegumentary leishmaniasis, a disease caused by protozoan parasites of the genus
Leishmania, is a major public health problem in many regions of Latin America. Its diagnosis …

Skin parasite landscape determines host infectiousness in visceral leishmaniasis

JSP Doehl, Z Bright, S Dey, H Davies, J Magson… - Nature …, 2017 - nature.com
Increasing evidence suggests that the infectiousness of patients for the sand fly vector of
visceral leishmaniasis is linked to parasites found in the skin. Using a murine model that …

Molecular detection and identification of Leishmania DNA and blood meal analysis in Phlebotomus (Larroussius) species

L Remadi, N Chargui, M Jimenez… - PLoS neglected …, 2020 - journals.plos.org
Background Phlebotomus (Larroussius) perniciosus and Canis familiaris are respectively
the only confirmed vector and reservoir for the transmission of Leishmania (L.) infantum …

Comparison and clinical validation of qPCR assays targeting Leishmania 18S rDNA and HSP70 genes in patients with American Tegumentary Leishmaniasis

CPB Filgueira, OC Moreira… - PLoS neglected …, 2020 - journals.plos.org
Leishmaniasis is a worldwide neglected disease, encompassing asymptomatic infections
and different clinical forms, such as American Tegumentary Leishmaniasis (ATL) which is …

Analytical Performance of Four Polymerase Chain Reaction (PCR) and Real Time PCR (qPCR) Assays for the Detection of Six Leishmania Species DNA in Colombia

CM León, M Muñoz, C Hernández, MS Ayala… - Frontiers in …, 2017 - frontiersin.org
Leishmaniasis comprises a spectrum of parasitic diseases caused by protozoans of the
genus Leishmania. Molecular tools have been widely employed for the detection of …

A vaccine therapy for canine visceral leishmaniasis promoted significant improvement of clinical and immune status with reduction in parasite burden

BM Roatt, RDO Aguiar-Soares, LES Reis… - Frontiers in …, 2017 - frontiersin.org
Herein, we evaluated the treatment strategy employing a therapeutic heterologous vaccine
composed of antigens of Leishmania braziliensis associated with MPL adjuvant (LBMPL …

[HTML][HTML] Is Leishmania (Viannia) braziliensis parasite load associated with disease pathogenesis?

LOR Pereira, RB Moreira, MP de Oliveira… - International Journal of …, 2017 - Elsevier
Summary Background Leishmania (Viannia) braziliensis is the main etiological agent of
tegumentary leishmaniasis in the Americas. Parasite molecular diversity and host immune …

Livestock and rodents within an endemic focus of Visceral Leishmaniasis are not reservoir hosts for Leishmania donovani

AK Kushwaha, A Shukla, BM Scorza… - PLoS neglected …, 2022 - journals.plos.org
Leishmaniasis on the Indian subcontinent is thought to have an anthroponotic transmission
cycle. There is no direct evidence that a mammalian host other than humans can be infected …