Advances in spatial transcriptomics and its applications in cancer research

Y Jin, Y Zuo, G Li, W Liu, Y Pan, T Fan, X Fu, X Yao… - Molecular Cancer, 2024 - Springer
Malignant tumors have increasing morbidity and high mortality, and their occurrence and
development is a complicate process. The development of sequencing technologies …

[HTML][HTML] Scoping Review: Methods and Applications of Spatial Transcriptomics in Tumor Research

K Maciejewski, P Czerwinska - Cancers, 2024 - mdpi.com
Simple Summary Spatial transcriptomics is a technique of measuring gene expression with
spatial resolution on a tissue slide, which is especially useful in cancer research. This …

Single-cell multi-omics sequencing uncovers region-specific plasticity of glioblastoma for complementary therapeutic targeting

X Wang, Q Sun, T Liu, H Lu, X Lin, W Wang, Y Liu… - Science …, 2024 - science.org
Glioblastoma (GBM) cells are highly heterogeneous and invasive, leading to treatment
resistance and relapse. However, the molecular regulation in and distal to tumors remains …

Neurosurgical application of olaparib from a thermo-responsive paste potentiates DNA damage to prolong survival in malignant glioma

R Serra, SJ Smith, J Rowlinson, N Gorelick… - British journal of …, 2024 - nature.com
Background There is increased pan-cancer specific interest in repurposing the poly
adenosine diphosphate-ribose polymerase-1 (PARP-1) inhibitor, olaparib, for newly …

The wnt/pyruvate kinase, muscle axis plays an essential role in the differentiation of mouse neuroblastoma cells

C Lei, J Wang, X Zhang, X Ge, W Zhao, X Li… - Neurochemistry …, 2024 - Elsevier
Neuronal differentiation and neurite growth are essential processes in nervous system
development and are regulated by several factors. Although all-trans retinoic acid (ATRA) …

Nuclear receptor 4A1 facilitates complete Freund's adjuvant-induced inflammatory pain in rats by promoting ferroptosis in spinal glial cells

Y Deng, R Xuan, Z Qiu, P Xiang, Y Guo, L Xu… - Brain, Behavior, and …, 2024 - Elsevier
Glial cell-induced neuroinflammation in the spinal cord is the critical pathology underlying
complete Freund's adjuvant (CFA)-induced inflammatory pain. Previously, we showed that …

Metabolomic characterisation of the glioblastoma invasive margin reveals a region-specific signature

J Wood, SJ Smith, M Castellanos-Uribe, A Lourdusamy… - Heliyon, 2024 - cell.com
Isocitrate dehydrogenase wild-type glioblastoma (GBM) is characterised by a
heterogeneous genetic landscape resulting from dynamic competition between tumour …

[HTML][HTML] Complex Diagnostic Challenges in Glioblastoma: The Role of 18F-FDOPA PET Imaging

D Sipos, Z Debreczeni-Máté, Z Ritter, O Freihat… - Pharmaceuticals, 2024 - mdpi.com
Glioblastoma multiforme (GBM) remains one of the most aggressive and lethal forms of brain
cancer, characterized by rapid proliferation and diffuse infiltration into the surrounding brain …

Clinical Application of the Association between Genetic Alteration and Intraoperative Fluorescence Activity of 5-Aminolevulinic Acid during the Resection of Brain …

HY Jeong, WJ Suh, SH Kim, TM Nam, JH Jang, KH Kim… - Cancers, 2023 - mdpi.com
Simple Summary Although 5-aminolevulinic acid (ALA) is commonly used in glioma surgery
to identify cell infiltration, recent studies have shown its successful use in brain metastasis …

The addition of 5-aminolevulinic acid to HBSS protects testis grafts during hypothermic transportation: a novel preservation strategy

MH Ma, PG Chen, JX He, HC Chen, ZH Xu… - Asian Journal of …, 2024 - journals.lww.com
The aim of this investigation was to determine the optimal storage medium for testicular
hypothermic transportation and identify the ideal concentration for the application of the …