Advances in spatial transcriptomics and its applications in cancer research
Y Jin, Y Zuo, G Li, W Liu, Y Pan, T Fan, X Fu, X Yao… - Molecular Cancer, 2024 - Springer
Malignant tumors have increasing morbidity and high mortality, and their occurrence and
development is a complicate process. The development of sequencing technologies …
development is a complicate process. The development of sequencing technologies …
[HTML][HTML] Scoping Review: Methods and Applications of Spatial Transcriptomics in Tumor Research
K Maciejewski, P Czerwinska - Cancers, 2024 - mdpi.com
Simple Summary Spatial transcriptomics is a technique of measuring gene expression with
spatial resolution on a tissue slide, which is especially useful in cancer research. This …
spatial resolution on a tissue slide, which is especially useful in cancer research. This …
Single-cell multi-omics sequencing uncovers region-specific plasticity of glioblastoma for complementary therapeutic targeting
Glioblastoma (GBM) cells are highly heterogeneous and invasive, leading to treatment
resistance and relapse. However, the molecular regulation in and distal to tumors remains …
resistance and relapse. However, the molecular regulation in and distal to tumors remains …
Neurosurgical application of olaparib from a thermo-responsive paste potentiates DNA damage to prolong survival in malignant glioma
R Serra, SJ Smith, J Rowlinson, N Gorelick… - British journal of …, 2024 - nature.com
Background There is increased pan-cancer specific interest in repurposing the poly
adenosine diphosphate-ribose polymerase-1 (PARP-1) inhibitor, olaparib, for newly …
adenosine diphosphate-ribose polymerase-1 (PARP-1) inhibitor, olaparib, for newly …
The wnt/pyruvate kinase, muscle axis plays an essential role in the differentiation of mouse neuroblastoma cells
C Lei, J Wang, X Zhang, X Ge, W Zhao, X Li… - Neurochemistry …, 2024 - Elsevier
Neuronal differentiation and neurite growth are essential processes in nervous system
development and are regulated by several factors. Although all-trans retinoic acid (ATRA) …
development and are regulated by several factors. Although all-trans retinoic acid (ATRA) …
Nuclear receptor 4A1 facilitates complete Freund's adjuvant-induced inflammatory pain in rats by promoting ferroptosis in spinal glial cells
Y Deng, R Xuan, Z Qiu, P Xiang, Y Guo, L Xu… - Brain, Behavior, and …, 2024 - Elsevier
Glial cell-induced neuroinflammation in the spinal cord is the critical pathology underlying
complete Freund's adjuvant (CFA)-induced inflammatory pain. Previously, we showed that …
complete Freund's adjuvant (CFA)-induced inflammatory pain. Previously, we showed that …
Metabolomic characterisation of the glioblastoma invasive margin reveals a region-specific signature
J Wood, SJ Smith, M Castellanos-Uribe, A Lourdusamy… - Heliyon, 2024 - cell.com
Isocitrate dehydrogenase wild-type glioblastoma (GBM) is characterised by a
heterogeneous genetic landscape resulting from dynamic competition between tumour …
heterogeneous genetic landscape resulting from dynamic competition between tumour …
[HTML][HTML] Complex Diagnostic Challenges in Glioblastoma: The Role of 18F-FDOPA PET Imaging
Glioblastoma multiforme (GBM) remains one of the most aggressive and lethal forms of brain
cancer, characterized by rapid proliferation and diffuse infiltration into the surrounding brain …
cancer, characterized by rapid proliferation and diffuse infiltration into the surrounding brain …
Clinical Application of the Association between Genetic Alteration and Intraoperative Fluorescence Activity of 5-Aminolevulinic Acid during the Resection of Brain …
HY Jeong, WJ Suh, SH Kim, TM Nam, JH Jang, KH Kim… - Cancers, 2023 - mdpi.com
Simple Summary Although 5-aminolevulinic acid (ALA) is commonly used in glioma surgery
to identify cell infiltration, recent studies have shown its successful use in brain metastasis …
to identify cell infiltration, recent studies have shown its successful use in brain metastasis …
The addition of 5-aminolevulinic acid to HBSS protects testis grafts during hypothermic transportation: a novel preservation strategy
MH Ma, PG Chen, JX He, HC Chen, ZH Xu… - Asian Journal of …, 2024 - journals.lww.com
The aim of this investigation was to determine the optimal storage medium for testicular
hypothermic transportation and identify the ideal concentration for the application of the …
hypothermic transportation and identify the ideal concentration for the application of the …