Obesity is a growing problem worldwide and is associated with a range of comorbidities,
including cognitive dysfunction. In this review we will address the evidence that obesity and …

Alzheimer's disease (AD) should be regarded as a degenerative metabolic disease caused
by brain insulin resistance and deficiency, and overlapping with the molecular, biochemical …

Hyperinsulinemia is associated with obesity and pancreatic islet hyperplasia, but whether
insulin causes these phenomena or is a compensatory response has remained unsettled for …

Growing evidence supports the concept that Alzheimer's disease (AD) is fundamentally a
metabolic disease with molecular and biochemical features that correspond with diabetes …

Alzheimer's disease (AD) has characteristic histopathological, molecular, and biochemical
abnormalities, including cell loss; abundant neurofibrillary tangles; dystrophic neurites; …

Alzheimer's disease [AD] is the most common cause of dementia in North America. Despite
30+ years of intense investigation, the field lacks consensus regarding the etiology and …

Alzheimer's disease (AD) is the 3rd most costly disease and the leading cause of dementia.
It can linger for many years, but ultimately is fatal, the 6th leading cause of death …

There is growing evidence that obesity has deleterious effects on the brain and cognitive
function in the elderly population. However, the specific mechanisms through which aging …

Obesity-induced diabetes is associated with chronic inflammation and is considered a risk
factor for neurodegeneration. We tested the hypothesis that an AMP-activated protein kinase …

Insulin regulates glucose uptake and storage in peripheral tissues, and has been shown to
act within the hypothalamus to acutely regulate food intake and metabolism. The machinery …