Many human birth defects and neurodevelopmental disorders are caused by loss-of-function
mutations in a single copy of transcription factor (TF) and chromatin regulator genes …

Two decades of research into functions of the ubiquitous transcription factor HIF have
revealed pervasive roles in development, oxygen homeostasis, metabolism, cancer and …

Both short and long sleep are associated with an adverse lipid profile, likely through different
biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we …

Although a growing body of evidence indicates that phenotypic plasticity exhibited by
glioblastoma cells plays a central role in tumor development and post-therapy recurrence …

Aberrations in the excitatory/inhibitory balance within the brain have been associated with
both intellectual disability (ID) and schizophrenia (SZ). The bHLH-PAS transcription factors …

Objective Several deletions of chromosome 6q, including SIM1, were reported in obese
patients with developmental delay. Furthermore, rare loss‐of‐function SIM1 mutations were …

Abstract The basic-Helix-Loop-Helix Per-Arnt-Sim (PAS) homology domain (bHLH-PAS)
transcription factor (TF) family comprises critical biological sensors of physiological (hypoxia …

Single-minded 2 (SIM2) is a neuron-enriched basic Helix–Loop–Helix/PER–ARNT–SIM
(bHLH/PAS) transcription factor essential for mammalian survival. SIM2 is located within the …

Transcription factors of the basic helix‐loop‐helix (bHLH) PER‐ARNT‐SIM (PAS) family
generally have critical and nonredundant biological roles, but some bHLH PAS proteins …

Both short and long sleep are associated with an adverse lipid profile, likely through different
biological pathways. To provide new insights in the biology of sleep-associated adverse …