Disentangling the many layers of eukaryotic transcriptional regulation
KM Lelli, M Slattery, RS Mann - Annual review of genetics, 2012 - annualreviews.org
Regulation of gene expression in eukaryotes is an extremely complex process. In this
review, we break down several critical steps, emphasizing new data and techniques that …
review, we break down several critical steps, emphasizing new data and techniques that …
The soft touch: low-affinity transcription factor binding sites in development and evolution
Transcription factor proteins regulate gene expression by binding to specific DNA regions.
Most studies of transcription factor binding sites have focused on the highest affinity sites for …
Most studies of transcription factor binding sites have focused on the highest affinity sites for …
Low affinity binding site clusters confer hox specificity and regulatory robustness
In animals, Hox transcription factors define regional identity in distinct anatomical domains.
How Hox genes encode this specificity is a paradox, because different Hox proteins bind …
How Hox genes encode this specificity is a paradox, because different Hox proteins bind …
UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein–DNA interactions
MA Hume, LA Barrera, SS Gisselbrecht… - Nucleic acids …, 2015 - academic.oup.com
Abstract The Universal PBM Resource for Oligonucleotide Binding Evaluation (UniPROBE)
serves as a convenient source of information on published data generated using universal …
serves as a convenient source of information on published data generated using universal …
Genomic regions flanking E-box binding sites influence DNA binding specificity of bHLH transcription factors through DNA shape
DNA sequence is a major determinant of the binding specificity of transcription factors (TFs)
for their genomic targets. However, eukaryotic cells often express, at the same time, TFs with …
for their genomic targets. However, eukaryotic cells often express, at the same time, TFs with …
Evolution of transcription factor function as a mechanism for changing metazoan developmental gene regulatory networks
AM Cheatle Jarvela, VF Hinman - Evodevo, 2015 - Springer
The form that an animal takes during development is directed by gene regulatory networks
(GRNs). Developmental GRNs interpret maternally deposited molecules and externally …
(GRNs). Developmental GRNs interpret maternally deposited molecules and externally …
Proteome-wide profiling of activated transcription factors with a concatenated tandem array of transcription factor response elements
C Ding, DW Chan, W Liu, M Liu, D Li… - Proceedings of the …, 2013 - National Acad Sciences
Transcription factors (TFs) are families of proteins that bind to specific DNA sequences, or TF
response elements (TFREs), and function as regulators of many cellular processes …
response elements (TFREs), and function as regulators of many cellular processes …
Copper affects the binding of HIF-1α to the critical motifs of its target genes
Z Wu, W Zhang, YJ Kang - Metallomics, 2019 - academic.oup.com
Copper (Cu) regulates hypoxia-inducible factor-1 (HIF-1) transcription activity by affecting
the selectivity of HIF-1α binding to the promoters of affected genes. In hypoxia, Cu is …
the selectivity of HIF-1α binding to the promoters of affected genes. In hypoxia, Cu is …
Specification of the somatic musculature in Drosophila
KC Dobi, VK Schulman… - Wiley Interdisciplinary …, 2015 - Wiley Online Library
The somatic muscle system formed during Drosophila embryogenesis is required for larvae
to hatch, feed, and crawl. This system is replaced in the pupa by a new adult muscle set …
to hatch, feed, and crawl. This system is replaced in the pupa by a new adult muscle set …
Highly parallel assays of tissue-specific enhancers in whole Drosophila embryos
Transcriptional enhancers are a primary mechanism by which tissue-specific gene
expression is achieved. Despite the importance of these regulatory elements in …
expression is achieved. Despite the importance of these regulatory elements in …