The role of gut microbiota in the pathogenesis of colorectal cancer

Q Zhu, R Gao, W Wu, H Qin - Tumor Biology, 2013 - Springer
The human gastrointestinal tract harbors a complex and abundant microbial community that
can reach levels as high as 10 13–10 14 microorganisms in the colon. These …

Integrating immunologic signaling networks: the JAK/STAT pathway in colitis and colitis-associated cancer

S Zundler, MF Neurath - Vaccines, 2016 - mdpi.com
Cytokines are believed to be crucial mediators of chronic intestinal inflammation in
inflammatory bowel diseases (IBD) such as Crohn's disease (CD) and ulcerative colitis (UC) …

Helicobacter pylori promotes colorectal carcinogenesis by deregulating intestinal immunity and inducing a mucus-degrading microbiota signature

A Ralser, A Dietl, S Jarosch, V Engelsberger… - Gut, 2023 - gut.bmj.com
Objective Helicobacter pylori infection is the most prevalent bacterial infection worldwide.
Besides being the most important risk factor for gastric cancer development, epidemiological …

Signaling pathways bridging microbial-triggered inflammation and cancer

MJ Kipanyula, PFS Etet, L Vecchio, M Farahna… - Cellular signalling, 2013 - Elsevier
Microbial-triggered inflammation protects against pathogens and yet can paradoxically
cause considerable secondary damage to host tissues that can result in tissue fibrosis and …

[HTML][HTML] Lipopolysaccharide increases the release of VEGF-C that enhances cell motility and promotes lymphangiogenesis and lymphatic metastasis through the …

G Zhu, Q Huang, Y Huang, W Zheng, J Hua, S Yang… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Lipopolysaccharide (LPS) exists in the outer membrane of Gram-negative bacteria.
Colorectal normal epithelium and colorectal cancer cells in situ are continuously exposed to …

[HTML][HTML] Participation of microbiota in the development of gastric cancer

LL Wang, XJ Yu, SH Zhan, SJ Jia, ZB Tian… - World journal of …, 2014 - ncbi.nlm.nih.gov
There are a large number of bacteria inhabiting the human body, which provide benefits for
the health. Alterations of microbiota participate in the pathogenesis of diseases. The gastric …

Baicalein, an enteric microbial metabolite, suppresses gut inflammation and cancer progression in ApcMin/+ mice

CZ Wang, CF Zhang, Y Luo, H Yao, C Yu… - Clinical and …, 2020 - Springer
Objective Chronic inflammation is recognized as a risk factor for colorectal cancer (CRC)
development. Baicalin (BI), a major constituent in an anti-inflammatory herb Scutellaria …

Multiple infections by EBV, HCMV and Helicobacter pylori are highly frequent in patients with chronic gastritis and gastric cancer from Southwest Mexico: An …

O Del Moral-Hernández, CA Castañón-Sánchez… - Medicine, 2019 - journals.lww.com
The chronic inflammation and damage to the gastric epithelium induced by Helicobacter
pylori (H. pylori) are the main risk factors for gastric cancer development. Epstein-Barr virus …

American ginseng attenuates colitis-associated colon carcinogenesis in mice: Impact on gut microbiota and metabolomics

CZ Wang, C Yu, XD Wen, L Chen, CF Zhang… - Cancer Prevention …, 2016 - AACR
Inflammatory bowel disease is a risk factor for colorectal cancer initiation and development.
In this study, the effects of American ginseng on chemically induced colitis and colon …

Evolving concepts: how diet and the intestinal microbiome act as modulators of breast malignancy

I Shapira, K Sultan, A Lee… - International Scholarly …, 2013 - Wiley Online Library
The intestinal microbiome plays an important role in human physiology. Next‐generation
sequencing technologies, knockout and gnotobiotic mouse models, fecal transplant data …