Peptides are fragments of proteins that carry out biological functions. They act as signaling
entities via all domains of life and interfere with protein-protein interactions, which are …

It has been known for many years that the angiotensin-converting enzyme 2 (ACE2) is a cell
surface enzyme involved in the regulation of blood pressure. More recently, it was proven …

Cardiovascular diseases (CVDs) are the main contributors to global morbidity and mortality.
Major pathogenic phenotypes of CVDs include the development of endothelial dysfunction …

Background, Aims, Methods, Results, Conclusions: Severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) is a global challenge due to its ability to mutate into variants …

Diminazene aceturate (DIZE) is a putative angiotensin-converting enzyme 2 (ACE2)
activator and angiotensin type 1 receptor antagonist (AT1R). Its simple chemical structure …

The occurrence of the SARS-CoV-2, the virus responsible for COVID-19, has rapidly
become a pandemic, resulting in devastating effects to the global economy and public …

The octapeptide hormone angiotensin II is one of the most studied peptides with the aim of
designing and synthesizing non-peptide mimetics for oral administration. To achieve this …

Atherosclerosis and nonalcoholic fatty liver disease are leading causes of morbidity and
mortality in the Western countries. The renin–angiotensin system (RAS) with its two main …

Endothelial cell (EC) barrier dysfunction and increased adhesion of immune inflammatory
cells to ECs crucially contribute to acute lung injury (ALI). Angiotensin-converting enzyme 2 …

The entry of SARS-CoV-2 into host cells involves the interaction between the viral spike
protein and the human angiotensin-converting enzyme 2 (ACE2) receptor. Given that the …