Methylation of arginine residues by protein arginine methyltransferases (PRMTs) is involved
in the regulation of fundamental cellular processes, including transcription, RNA processing …

In recent years, there has been a tremendous development of biotechnological,
pharmacological, and medical techniques which can be implemented in the functional …

The PRMT5• MTA complex has recently emerged as a new synthetically lethal drug target
for the treatment of MTAP-deleted cancers. Here, we report the discovery of development …

As a predominant type II protein arginine methyltransferase, PRMT5 plays critical roles in
various normal cellular processes by catalyzing the mono-and symmetrical dimethylation of …

Abstract Protein arginine methyltransferases 5 (PRMT5), a therapeutic target whose main
physiological function is mono-and symmetric dimethylation of arginine, has drawn …

Arginine methylation is a ubiquitous post-translational modification. Three predominant
types of arginine-guanidino methylation occur in Eukarya: mono (Rme1/MMA), symmetric …

Cyclic GMP-AMP synthase (cGAS) functions as an essential DNA sensor, which senses the
cytoplasmic double-stranded DNA and activates the antiviral response. However, the …

Phagocytosis is a fundamental immune function against foreign microorganisms and
abnormal cells, and it is also a bridge between innate and adaptive immunity. Blood as the …

Immunological self-tolerance is established in the thymus by the expression of virtually all
self-antigens, including tissue-restricted antigens (TRAs) and cell-type–restricted antigens …

Since the discovery of protein arginine methyltransferase 5 (PRMT5) and the resolution of its
structure, an increasing number of papers have investigated and delineated the structural …