The bacterial multienzyme polyketide synthases (PKSs) produce a diverse array of products
that have been developed into medicines, including antibiotics and anticancer agents. The …

Covering: 2002 to September 2009 In recent years, a number of gene clusters involved in
the biosynthesis of polyketide compounds have been characterized and the genes have …

Covering: 1995 to 2006 The synthesis of secondary metabolites by microorganisms,
specifically antibiotics, is of great scientific and economic importance. The onset (control and …

Since the discovery of streptomycin, actinomycetes have been a useful source for new
antibiotics, but there have been diminishing rates of new finds since the 1960s. The …

Polyketides comprise one of the major families of natural products. They are found in a wide
variety of bacteria, fungi, and plants and include a large number of medically important …

Two new macrolides from the pikromycin biosynthetic pathway of Streptomyces venezuelae,
neopikromycin (9) and novapikromycin (10), were identified and structurally characterized …

The cytochrome P450 enzyme is one of the most versatile redox proteins and it is
responsible for the oxidative metabolism of a wide variety of endogenous and exogenous …

The impact of COVID-19's unexpected outbreak forced the scientific community to seek
alternative treatment methods in order to overcome the hindrance of traditional medicine in …

The macrolide antibiotics are biosynthesized by initial assembly of a macrolactone ring,
followed by a series of post-polyketide (PKS) modifications. In general, the additional …

As one of the most common classes of natural products, polyketides are made by nearly all
types of organisms. Produced by bacteria and fungi alike, they are a structurally diverse …