The mammalian cerebral cortex is the pinnacle of brain evolution, reaching its maximum
complexity in terms of neuron number, diversity and functional circuitry. The emergence of …

During prenatal brain development, ion channels are ubiquitous across several cell types,
including progenitor cells and migrating neurons but their function has not been clear. In the …

Channelopathies are disorders caused by abnormal ion channel function in differentiated
excitable tissues. We discovered a unique neurodevelopmental channelopathy resulting …

The neocortex exhibits a six-layered structure that is formed by radial migration of excitatory
neurons, for which the multipolar-to-bipolar transition of immature migrating multipolar …

In the developing brain, neurons are produced from neural stem cells termed radial glia [1,
2]. Radial glial progenitors span the neuroepithelium, extending long basal processes to …

Calcium influx can be stimulated by various intra-and extracellular signals to set coordinated
gene expression programs into motion. As such, the precise regulation of intracellular …

The calcium/calmodulin-dependent protein kinase II (CaMKII) is a ubiquitous and central
player in Ca2+ signaling that is best known for its functions in the brain. In particular, the α …

Abstract Calcium ion (Ca 2+) is not only an intracellular second messenger, but also
functions as an important messenger outside cells for intercellular communications. It is …

Sodium (Na+) electrochemical gradients established by Na+/K+ ATPase activity drives the
transport of ions, minerals, and sugars in both excitable and non-excitable cells. Na+ …

Collective cell migration mediates multiple tissue morphogenesis processes. Yet how multi-
dimensional mesenchymal cell movements are coordinated remains mostly unknown. Here …