Paleoproteomics

C Warinner, K Korzow Richter, MJ Collins - Chemical reviews, 2022 - ACS Publications
Paleoproteomics, the study of ancient proteins, is a rapidly growing field at the intersection of
molecular biology, paleontology, archaeology, paleoecology, and history. Paleoproteomics …

Proteomics beyond trypsin

L Tsiatsiani, AJR Heck - The FEBS journal, 2015 - Wiley Online Library
Peptide‐centered shotgun analysis of proteins has been the core technology in mass
spectrometry based proteomics and has enabled numerous biological discoveries, such as …

Top or middle? Up or down? Toward a standard lexicon for protein top-down and allied mass spectrometry approaches

F Lermyte, YO Tsybin, PB O'Connor… - Journal of the American …, 2019 - ACS Publications
In recent years, there has been increasing interest in top-down mass spectrometry (TDMS)
approaches for protein analysis, driven both by technological advancements and efforts …

Toward an optimized workflow for middle-down proteomics

A Cristobal, F Marino, H Post… - Analytical …, 2017 - ACS Publications
Mass spectrometry (MS)-based proteomics workflows can crudely be classified into two
distinct regimes, targeting either relatively small peptides (ie, 0.7 kDa< M w< 3.0 kDa) or …

Proteomic discovery of non-invasive biomarkers of localized prostate cancer using mass spectrometry

A Khoo, LY Liu, JO Nyalwidhe, OJ Semmes… - Nature Reviews …, 2021 - nature.com
Prostate cancer is the second most frequently diagnosed non-skin cancer in men worldwide.
Patient outcomes are remarkably heterogeneous and the best existing clinical prognostic …

Uncovering the impacts of alternative splicing on the proteome with current omics techniques

M Reixachs‐Solé, E Eyras - Wiley Interdisciplinary Reviews …, 2022 - Wiley Online Library
The high‐throughput sequencing of cellular RNAs has underscored a broad effect of isoform
diversification through alternative splicing on the transcriptome. Moreover, the differential …

Middle-down approach: a choice to sequence and characterize proteins/proteomes by mass spectrometry

PB Pandeswari, V Sabareesh - RSC advances, 2019 - pubs.rsc.org
Owing to rapid growth in the elucidation of genome sequences of various organisms,
deducing proteome sequences has become imperative, in order to have an improved …

Determination of A1 and A2 β-casein in milk using characteristic thermolytic peptides via liquid chromatography-mass spectrometry

Z Liu, S Pan, P Wu, M Li, D Liang - Molecules, 2023 - mdpi.com
β-casein, a protein in milk and dairy products, has two main variant forms termed as A1 and
A2. A1 β-casein may have adverse effects on humans. The fact that there is only one amino …

Mass spectrometry based proteomics as foodomics tool in research and assurance of food quality and safety

U Andjelković, D Josić - Trends in Food Science & Technology, 2018 - Elsevier
Background As a comprehensive discipline that studies food and nutrition, foodomics
requires reliable qualitative and quantitative information about the food proteome …

Self-Assembled Protein–Surfactant Nanoaggregates for Tunable Peptide Bond Hydrolysis by Polyoxometalate Nanoclusters

ND Savic, DE Salazar Marcano… - ACS Applied Nano …, 2022 - ACS Publications
The development of robust artificial proteases is of crucial importance for the study of
proteins since natural proteases only retain their proteolytic activity under specific …