Biology of the mRNA splicing machinery and its dysregulation in cancer providing therapeutic opportunities
M Blijlevens, J Li, VW van Beusechem - International journal of molecular …, 2021 - mdpi.com
Dysregulation of messenger RNA (mRNA) processing—in particular mRNA splicing—is a
hallmark of cancer. Compared to normal cells, cancer cells frequently present aberrant …
hallmark of cancer. Compared to normal cells, cancer cells frequently present aberrant …
Challenging cellular homeostasis: Spatial and temporal regulation of miRNAs
N van Wijk, K Zohar, M Linial - International journal of molecular sciences, 2022 - mdpi.com
Mature microRNAs (miRNAs) are single-stranded non-coding RNA (ncRNA) molecules that
act in post-transcriptional regulation in animals and plants. A mature miRNA is the end …
act in post-transcriptional regulation in animals and plants. A mature miRNA is the end …
[HTML][HTML] Screening of miRNAs as prognostic biomarkers and their associated hub targets across Hepatocellular carcinoma using survival-based bioinformatics …
Background The hepatocellular carcinoma (HCC) incident rate is gradually increasing
yearly despite all the research and efforts taken by scientific communities and governing …
yearly despite all the research and efforts taken by scientific communities and governing …
A novel ceRNA regulatory network involving the long non-coding antisense RNA SPACA6P-AS, miR-125a and its mRNA targets in hepatocarcinoma cells
A Di Palo, C Siniscalchi, N Mosca, A Russo… - International Journal of …, 2020 - mdpi.com
MicroRNAs (miRNA), and more recently long non-coding RNAs (lncRNA), are emerging as
a driving force for hepatocellular carcinoma (HCC), one of the leading causes of cancer …
a driving force for hepatocellular carcinoma (HCC), one of the leading causes of cancer …
[HTML][HTML] Crosstalk between Long Non-Coding RNA and Spliceosomal microRNA as a Novel Biomarker for Cancer
M Arafat, R Sperling - Non-coding RNA, 2023 - mdpi.com
Non-coding RNAs (ncRNAs) play diverse roles in regulating cellular processes and have
been implicated in pathological conditions, including cancer, where interactions between …
been implicated in pathological conditions, including cancer, where interactions between …
Identification of extracellular vesicles-transported miRNAs in Erlotinib-resistant head and neck squamous cell carcinoma
Y Zheng, A Song, Y Zhou, Y Zhong, W Zhang… - Journal of cell …, 2020 - Springer
Erlotinib is an oral tyrosine kinase inhibitor of epidermal growth factor receptor (EGFR)
pathway. Although our previous study has proved the efficacy of Erlotinib in head and neck …
pathway. Although our previous study has proved the efficacy of Erlotinib in head and neck …
[HTML][HTML] Preoperative serum microRNAs as potential prognostic biomarkers in ovarian clear cell carcinoma
K Suzuki, A Yokoi, K Yoshida, T Kato… - Journal of …, 2023 - ncbi.nlm.nih.gov
Objective Ovarian clear cell carcinoma (OCCC) is a subtype of epithelial ovarian carcinoma
with poor prognosis. However, no effective biomarkers have been established for predicting …
with poor prognosis. However, no effective biomarkers have been established for predicting …
Spliceosome-associated microRNAs signify breast cancer cells and portray potential novel nuclear targets
S Mahlab-Aviv, K Zohar, Y Cohen, AR Peretz… - International journal of …, 2020 - mdpi.com
MicroRNAs (miRNAs) act as negative regulators of gene expression in the cytoplasm.
Previous studies have identified the presence of miRNAs in the nucleus. Here we study …
Previous studies have identified the presence of miRNAs in the nucleus. Here we study …
[HTML][HTML] miR-4716–3p and the target AKT2 Gene/rs2304186 SNP are associated with blood cancer pathogenesis in Pakistani population
AKT2 is crucial for cancer cells' invasion, metastasis, and survival. It is a possible
downstream gene target of cancer glycolysis-related microRNAs. The study investigated the …
downstream gene target of cancer glycolysis-related microRNAs. The study investigated the …
[HTML][HTML] A miRNA-7704/IL2RB/AKT feedback loop regulates tumorigenesis and chemoresistance in ovarian cancer
X Meng, X Liang, S Yang, D Wu, X Wang - Experimental Cell Research, 2024 - Elsevier
Ovarian cancer is one of the most common gynecological tumors worldwide. Despite the
availability of multiple treatments for ovarian cancer, its resistance to chemotherapy remains …
availability of multiple treatments for ovarian cancer, its resistance to chemotherapy remains …