Colorectal cancer (CRC) is one of the most common aggressive carcinoma types worldwide,
characterized by unfavorable curative effect and poor prognosis. Epidemiological data re …

Consistent evidence associates IGF-1 deficiency and metabolic syndrome. In this review, we
will focus on the metabolic effects of IGF-1, the concept of metabolic syndrome and its …

The pathophysiology of Polycystic Ovary Syndrome (PCOS) is quite complex and different
mechanisms could contribute to hyperandrogenism and anovulation, which are the main …

Accumulating epidemiological and experimental evidence indicates that nonalcoholic fatty
liver disease (NAFLD) has an intrauterine origin. Fetuses exposed to adverse prenatal …

This review resumes the association between mitochondrial function and diseases,
especially neurodegenerative diseases. Additionally, it summarizes the major role of IGF-1 …

Aims To investigate the associations of dyslipidemia with insulin resistance and β cell
function in individuals with normal glucose tolerance (NGT) and different categories of …

Cirrhosis represents the final stage of chronic liver damage, which can be due to different
factors such as alcohol, metabolic syndrome with liver steatosis, autoimmune diseases …

There is increasing evidence that hypercholesterolemia has an intrauterine developmental
origin. However, the pathogenesis of fetal‐originated is still lacking in a theoretical system …

Abstract Background Metabolic syndrome (MetS), characterized by obesity, hyperglycemia,
and abnormal blood lipid levels, is the pathological basis of many cardiovascular diseases …

Even though the liver synthesizes most of circulating IGF-1, it lacks its receptor under
physiological conditions. However, according to previous studies, a damaged liver …