A practical guide for induction of type-2 diabetes in rat: Incorporating a high-fat diet and streptozotocin

S Gheibi, K Kashfi, A Ghasemi - Biomedicine & pharmacotherapy, 2017 - Elsevier
Prevalence of diabetes, a serious public health problem is rapidly increasing worldwide.
Type-2 diabetes is the common form of diabetes characterized by insulin resistance and …

Modeling type 2 diabetes in rats using high fat diet and streptozotocin

S Skovsø - Journal of diabetes investigation, 2014 - Wiley Online Library
The pathology of type 2 diabetes is complex, with multiple stages culminating in a functional
β‐cell mass that is insufficient to meet the body's needs. Although the broad outlines of the …

Human mesenchymal stem cell derived exosomes alleviate type 2 diabetes mellitus by reversing peripheral insulin resistance and relieving β-cell destruction

Y Sun, H Shi, S Yin, C Ji, X Zhang, B Zhang, P Wu… - ACS …, 2018 - ACS Publications
Exosomes are nanosized extracellular vesicles (EVs) that show great promise in tissue
regeneration and injury repair as mesenchymal stem cell (MSC). MSC has been shown to …

A pH‐triggered self‐unpacking capsule containing zwitterionic hydrogel‐coated MOF nanoparticles for efficient oral exendin‐4 delivery

Y Zhou, Z Chen, D Zhao, D Li, C He… - Advanced …, 2021 - Wiley Online Library
Oral peptide or protein delivery is considered a revolutionary alternative to daily
subcutaneous injection; however, major challenges remain in terms of impediments of the …

[HTML][HTML] The characterization of high-fat diet and multiple low-dose streptozotocin induced type 2 diabetes rat model

M Zhang, XY Lv, J Li, ZG Xu, L Chen - Experimental diabetes …, 2008 - ncbi.nlm.nih.gov
Aim. Based on the previously established method, we developed a better and stable animal
model of type 2 diabetes mellitus by high-fat diet combined with multiple low-dose STZ …

Apigenin and naringenin regulate glucose and lipid metabolism, and ameliorate vascular dysfunction in type 2 diabetic rats

B Ren, W Qin, F Wu, S Wang, C Pan, L Wang… - European journal of …, 2016 - Elsevier
Vascular endothelial dysfunction is regarded as the initial step of vascular complications in
diabetes mellitus. This study investigated the amelioration of apigenin and naringenin in …

[HTML][HTML] Stability of a type 2 diabetes rat model induced by high-fat diet feeding with low-dose streptozotocin injection

X Guo, Y Wang, K Wang, B Ji, F Zhou - Journal of Zhejiang …, 2018 - ncbi.nlm.nih.gov
Objective: The present study aims at determining the stability of a popular type 2 diabetes rat
model induced by a high-fat diet combined with a low-dose streptozotocin injection …

Infusion of mesenchymal stem cells ameliorates hyperglycemia in type 2 diabetic rats: identification of a novel role in improving insulin sensitivity

Y Si, Y Zhao, H Hao, J Liu, Y Guo, Y Mu, J Shen… - Diabetes, 2012 - Am Diabetes Assoc
Infusion of mesenchymal stem cells (MSCs) has been shown to effectively lower blood
glucose in diabetic individuals, but the mechanism involved could not be adequately …

Combination of high-fat/high-fructose diet and low-dose streptozotocin to model long-term type-2 diabetes complications

DA Barrière, C Noll, G Roussy, F Lizotte, A Kessai… - Scientific Reports, 2018 - nature.com
The epidemic of type 2 diabetes mellitus (T2DM) is fueled by added fructose consumption.
Here, we thus combined high-fat/high-fructose diet, with multiple low-dose injections of …

Anti-hyperglycemic activity of rutin in streptozotocin-induced diabetic rats: an effect mediated through cytokines, antioxidants and lipid biomarkers.

NT Niture, AA Ansari, SR Naik - Indian journal of experimental …, 2014 - europepmc.org
Administration of rutin (50 and 100 mg/kg) and pioglitazone (10 mg/kg) orally for 3 weeks
treatment significantly improved body weight, reduced plasma glucose and glycosylated …