Cyclic guanosine monophosphate (cGMP), an important intracellular second messenger,
mediates cellular functional responses in all vital organs. Phosphodiesterase 5 (PDE5) is …

Abstract Heat shock protein (HSP) 90, an important component of the molecular chaperone
network, is closely concerned with cellular signaling pathways and stress response by …

Heart failure with preserved ejection fraction (HFpEF) is now the dominant form of heart
failure and one for which no efficacious therapies exist. Obesity and lipid mishandling …

Cyclic nucleotide phosphodiesterases (PDEs) modulate the neurohormonal regulation of
cardiac function by degrading cAMP and cGMP. In cardiomyocytes, multiple PDE isozymes …

Phosphodiesterases (PDEs) are a superfamily of enzymes that hydrolyze cyclic nucleotides.
While the 11 PDE subfamilies share common features, key differences confer signaling …

Oncology has seen growing use of newly developed targeted therapies. Although this has
resulted in dramatic improvements in progression-free and overall survival, challenges in …

Rab22a‐NeoF fusion protein has recently been reported as a promising target for
osteosarcoma lung metastasis. However, how this fusion protein is regulated in cells …

BACKGROUND: The major cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) has
emerged as a key mediator of inflammation that underlies cardiovascular disease. On …

Cardiac dysfunction has been recognized as a major contributor to mortality in sepsis, which
is closely associated with inflammatory reactions. The carboxy terminus of Hsc70-interacting …

Introduction Excessive immune activation induces tissue damage during infection.
Compared to external strategies to reconstruct immune homeostasis, host balancing ways …