Bifunctional stapled polypeptides and uses thereof
GL Verdine, TN Grossmann, RE Moellering… - US Patent …, 2015 - Google Patents
2010-11-15 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
Stabilized alpha helical peptides and uses thereof
LD Walensky, SJ Korsmeyer, G Verdine - US Patent 7,723,469, 2010 - Google Patents
Novel polypeptides and methods of making and using the same are described herein. The
polypeptides include cross linking (“hydrocarbon stapling”) moieties to provide a tether …
polypeptides include cross linking (“hydrocarbon stapling”) moieties to provide a tether …
Stabilized alpha helical peptides and uses thereof
LD Walensky, SJ Korsmeyer, GL Verdine - US Patent 8,796,418, 2014 - Google Patents
Novel polypeptides and methods of making and using the same are described herein. The
polypeptides include cross linking (“hydrocarbon stapling”) moieties to provide a tether …
polypeptides include cross linking (“hydrocarbon stapling”) moieties to provide a tether …
Stabilized alpha helical peptides and uses thereof
LD Walensky, SJ Korsmeyer, G Verdine - US Patent 8,198,405, 2012 - Google Patents
US8198405B2 - Stabilized alpha helical peptides and uses thereof - Google Patents
US8198405B2 - Stabilized alpha helical peptides and uses thereof - Google Patents Stabilized …
US8198405B2 - Stabilized alpha helical peptides and uses thereof - Google Patents Stabilized …
Biologically active peptidomimetic macrocycles
HM Nash, R Kapeller-Libermann… - US Patent App. 12 …, 2009 - Google Patents
The present invention provides biologically active peptidomimetic macrocycles with
improved properties rela tive to a corresponding crosslinked polypeptide. 0004. In one …
improved properties rela tive to a corresponding crosslinked polypeptide. 0004. In one …
Stitched polypeptides
GL Verdine, YW Kim - US Patent 8,592,377, 2013 - Google Patents
2008-08-27 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
Stabilized p53 peptides and uses thereof
US8889632B2 - Stabilized p53 peptides and uses thereof - Google Patents US8889632B2 -
Stabilized p53 peptides and uses thereof - Google Patents Stabilized p53 peptides and uses …
Stabilized p53 peptides and uses thereof - Google Patents Stabilized p53 peptides and uses …
Bis-sulfhydryl macrocyclization systems
HM Nash - US Patent 7,981,998, 2011 - Google Patents
US7981998B2 - Bis-sulfhydryl macrocyclization systems - Google Patents US7981998B2 -
Bis-sulfhydryl macrocyclization systems - Google Patents Bis-sulfhydryl macrocyclization …
Bis-sulfhydryl macrocyclization systems - Google Patents Bis-sulfhydryl macrocyclization …
Methods for preparing internally constrained peptides and peptidomimetics
P Arora, R Chapman - US Patent 8,071,541, 2011 - Google Patents
US PATENT DOCUMENTS 5,446,128 A 8, 1995 Kahn 5,710,245 A 1/1998 Kahn 5,859,184
A 1/1999 Kahn et al. 7,192,713 B1 3/2007 Verdine et al. 7,723.469 B2 5/2010 Walensky et …
A 1/1999 Kahn et al. 7,192,713 B1 3/2007 Verdine et al. 7,723.469 B2 5/2010 Walensky et …
Triazole macrocycle systems
HM Nash - US Patent 7,981,999, 2011 - Google Patents
The present invention provides novel peptidomimetic macro cycles and methods for their
preparation and use, as well as amino acid analogs and macrocycle-forming linkers, and …
preparation and use, as well as amino acid analogs and macrocycle-forming linkers, and …