[HTML][HTML] Overcoming cancer therapeutic bottleneck by drug repurposing

Z Zhang, L Zhou, N Xie, EC Nice, T Zhang… - Signal transduction and …, 2020 - nature.com
Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated
the development of the alternative strategy of drug repurposing, the development of old …

[HTML][HTML] Small molecules in the treatment of COVID-19

S Lei, X Chen, J Wu, X Duan, K Men - Signal transduction and targeted …, 2022 - nature.com
The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to
societies and economies. Until now, effective therapeutics against COVID-19 are in high …

From ancient herb to modern drug: Artemisia annua and artemisinin for cancer therapy

T Efferth - Seminars in cancer biology, 2017 - Elsevier
Artemisia annua L. is used throughout Asia and Africa as tea and press juice to treat malaria
and related symptomes (fever, chills). Its active ingredient, artemisinin (ARS), has been …

The immunosuppressive activity of artemisinin‐type drugs towards inflammatory and autoimmune diseases

T Efferth, F Oesch - Medicinal research reviews, 2021 - Wiley Online Library
The sesquiterpene lactone artemisinin from Artemisia annua L. is well established for
malaria therapy, but its bioactivity spectrum is much broader. In this review, we give a …

Anti-SARS-CoV-2 potential of artemisinins in vitro

R Cao, H Hu, Y Li, X Wang, M Xu, J Liu… - ACS Infectious …, 2020 - ACS Publications
The discovery of novel drug candidates with anti-severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) potential is critical for the control of the global COVID-19 …

[HTML][HTML] The use of antimalarial drugs against viral infection

S D'Alessandro, D Scaccabarozzi, L Signorini… - Microorganisms, 2020 - mdpi.com
In recent decades, drugs used to treat malaria infection have been shown to be beneficial for
many other diseases, including viral infections. In particular, they have received special …

Anti-malarial drug, artemisinin and its derivatives for the treatment of respiratory diseases

DHJ Cheong, DWS Tan, FWS Wong, T Tran - Pharmacological research, 2020 - Elsevier
Artemisinins are sesquiterpene lactones with a peroxide moiety that are isolated from the
herb Artemisia annua. It has been used for centuries for the treatment of fever and chills, and …

Plant-microbial interaction: The mechanism and the application of microbial elicitor induced secondary metabolites biosynthesis in medicinal plants

I Chamkhi, T Benali, T Aanniz, N El Menyiy… - Plant Physiology and …, 2021 - Elsevier
Plants and microbes interact with each other via different chemical signaling pathways. At
the risophere level, the microbes can secrete molecules, called elicitors, which act on their …

Artemisinins: pharmacological actions beyond anti-malarial

WE Ho, HY Peh, TK Chan, WSF Wong - Pharmacology & therapeutics, 2014 - Elsevier
Artemisinins are a family of sesquiterpene trioxane lactone anti-malarial agents originally
derived from Artemisia annua L. The anti-malarial action of artemisinins involves the …

Therapeutic potential of medicinal plants against COVID-19: The role of antiviral medicinal metabolites

T Khan, MA Khan, N Ullah, A Nadhman - Biocatalysis and agricultural …, 2021 - Elsevier
There are numerous trials underway to find treatment for the COVID-19 through testing
vaccines as well as existing drugs. Apart from the many synthetic chemical compounds …