Biological processes are naturally regulated with high spatial and temporal control, as is
perhaps most evident in metazoan embryogenesis. Chemical tools have been extensively …

It has recently been reported that thousands of covalently linked circular RNAs (circRNAs)
are expressed from human genomes. circRNAs emerge during RNA splicing. circRNAs are …

RNA-binding proteins (RBPs) play an essential role in regulating the function of RNAs in a
cellular context, but our ability to control RBP activity in time and space is limited. Here, we …

Synthetic oligonucleotides have been extensively applied tocontrol a wide range of
biological processes such as gene expression, gene repair, DNA replication, and protein …

Oligonucleotide-based therapeutics have attracted attention as an emerging modality that
includes the modulation of genes and their binding proteins related to diseases, allowing us …

External photocontrol over RNA function has emerged as a useful tool for studying nucleic
acid biology. Most current methods rely on fully synthetic nucleic acids with photocaged …

Translation of mRNA into protein is one of the most fundamental processes within biological
systems. Gene expression is tightly regulated both in space and time, often involving …

We describe a selective and mild chemical approach for controlling RNA hybridization,
folding, and enzyme interactions. Reaction of RNAs in aqueous buffer with an azide …

Photoresponsive DNA nanomaterials represent a new class of remarkable functional
materials. By adjusting the irradiation wavelength, light intensity, and exposure time, various …

Abstract Die Regulation biologischer Vorgänge in der Natur unterliegt einer strengen
räumlichen und zeitlichen Steuerung; eines der offensichtlichsten Beispiele ist die …