The development of therapeutic approaches for the induction of robust, long-lasting and
antigen-specific immune tolerance remains an important unmet clinical need for the …

Vaccines provide a powerful tool to modulate the immune system for human disease
prevention and treatment. Classical vaccines mainly initiate immune responses in the lymph …

Coeliac disease is an autoinflammatory condition caused by immune reactions to cereal
gluten proteins. Currently, the only available treatment for the condition is a lifelong …

The high prevalence and rising incidence of autoimmune diseases have become a
prominent public health issue. Autoimmune disorders result from the immune system …

Dendritic cells (DCs) are the major specialized antigen-presenting cells (APCs), play a key
role in initiating the body's immune response, maintain the balance of immunity. DCs can …

The prevalence of immune-mediated disorders, including autoimmune conditions and
allergies, is steadily increasing. However, current therapeutic approaches are often non …

Disease-modifying drugs have transformed the treatment options for many systemic
autoimmune diseases. However, an evolving understanding of disease mechanisms, which …

Extrahepatic nucleic acid delivery using polymers typically requires the synthesis and
purification of custom monomers, post-synthetic modifications, and incorporation of …

Polymeric nanoparticles (NPs) composed of poly (lactic-co-glycolic acid)(PLGA) have found
success in modulating antigen (Ag)-specific T cell responses for the treatment multiple …

Impairment of immune tolerance might cause autologous tissue damage or overactive
immune response against non-pathogenic molecules. Although autoimmune disease and …