The nervous system comprises a remarkably diverse and complex network of cell types,
which must communicate with one another with speed, reliability, and precision. Thus, the …

Microglia, the macrophages of the brain parenchyma, are key players in neurodegenerative
diseases such as Alzheimer's disease. These cells adopt distinct transcriptional subtypes …

Microglia are tissue-resident macrophages and professional phagocytes of the central
nervous system (CNS). In development, microglia-mediated phagocytosis is important for …

Clearing amyloid-β (Aβ) through immunotherapy is one of the most promising therapeutic
approaches to Alzheimer's disease (AD). Although several monoclonal antibodies against …

Brain metastasis, a serious complication of cancer, hinges on the initial survival,
microenvironment adaptation, and outgrowth of disseminated cancer cells. To understand …

Region-related heterogeneity and state transitions of microglia are important for brain
development and neurological pathogenesis. However, regional specialization and state …

Non-neuronal cells are key to the complex cellular interplay that follows central nervous
system insult. To understand this interplay, we generated a single-cell atlas of immune, glial …

Microglia serve critical remodeling roles that shape the developing nervous system,
responding to the changing neural environment with phagocytosis or soluble factor …

Cardiac macrophages represent a functionally diverse population of cells involved in
cardiac homeostasis, repair, and remodeling. With recent advancements in single-cell …

The neurobiology of Alzheimer's disease (AD) is unclear due to its multifactorial nature.
Although a wide range of studies revealed several pathomechanisms of AD, dementia is yet …