From resistance to resilience: Uncovering chemotherapeutic resistance mechanisms; insights from established models
Despite the tremendous advances in cancer treatment, resistance to chemotherapeutic
agents impedes higher success rates and accounts for major relapses in cancer therapy …
agents impedes higher success rates and accounts for major relapses in cancer therapy …
Pharmacogenetic Study of the Impact of ABCB1 Single Nucleotide Polymorphisms on the Response to Cyclosporine in Psoriasis Patients
A Chernov, D Kilina, T Smirnova, E Galimova - Pharmaceutics, 2022 - mdpi.com
Psoriasis is a chronic, T cell-mediated skin disease affecting 2–3% of the Caucasian
population. Cyclosporine A is a calcineurin inhibitor that acts selectively on T cells. The …
population. Cyclosporine A is a calcineurin inhibitor that acts selectively on T cells. The …
CRISPR/Cas9-induced knockout reveals the role of ABCB1 in the response to temozolomide, carmustine and lomustine in glioblastoma multiforme
L Radtke, A Majchrzak-Celińska, C Awortwe… - Pharmacological …, 2022 - Elsevier
Glioblastoma multiforme (GBM) is the most common malignant brain tumor with limited
therapeutic options. Besides surgery, chemotherapy using temozolomide, carmustine or …
therapeutic options. Besides surgery, chemotherapy using temozolomide, carmustine or …
Temozolomide-induced myelotoxicity and single nucleotide polymorphisms in the MGMT gene in patients with adult diffuse glioma: a single-institutional …
P Moitra, A Chatterjee, PK Kota, S Epari, V Patil… - Journal of Neuro …, 2022 - Springer
Purpose Nearly 10% of patients with adult diffuse glioma develop clinically significant
myelotoxicity while on temozolomide (TMZ) leading to treatment interruptions. This study …
myelotoxicity while on temozolomide (TMZ) leading to treatment interruptions. This study …
Association of the 1236C> T variant of the multidrug resistance 1 gene with esophageal squamous cell carcinoma development and prognosis
N Ghobadi, G Khalili-Tanha, M Mehramiz, M Maftooh… - Human Gene, 2023 - Elsevier
Background Esophageal squamous cell carcinoma (ESCC) is a common cause of cancer
related mortality. There is a growing body of evidence showing an association between …
related mortality. There is a growing body of evidence showing an association between …
Revisiting the effects of MDR1 Variants using computational approaches
T Gutman, T Tuller - RECOMB International Workshop on Comparative …, 2024 - Springer
P-glycoprotein, encoded by the MDR1 gene, is an ATP-dependent pump that exports
various substances out of cells. Its overexpression is related to multi drug resistance in many …
various substances out of cells. Its overexpression is related to multi drug resistance in many …
The Effect of Systemic Temozolomide on Learning, Emotional Behaviour, and Hippocampal Synaptic Plasticity: Implications for Chemotherapy-Induced Cognitive …
K Blewett - 2024 - search.proquest.com
Patients who undergo chemotherapy often complain of a persistent 'brain fog'that can be
present up to years after treatment ends. This fog is expressed as marked impairments in …
present up to years after treatment ends. This fog is expressed as marked impairments in …